The drug giving rise to the adverse effect should be identified by use of codes from categories T36-T50 with fifth or sixth character 5.

Use additional code(s) to specify:
manifestations of poisoning
underdosing or failure in dosage during medical and surgical care (Y63.6, Y63.8-Y63.9)
underdosing of medication regimen (Z91.12-, Z91.13-)

Code first  , for adverse effects, the nature of the adverse effect, such as:
  adverse effect NOS (T88.7)
  aspirin gastritis (K29.-)
  blood disorders (D56-D76)
  contact dermatitis (L23-L25)
  dermatitis due to substances taken internally (L27.-)
  nephropathy (N14.0-N14.2)

Includes:

  • adverse effect of correct substance properly administered
  • poisoning by overdose of substance
  • poisoning by wrong substance given or taken in error
  • underdosing by (inadvertently) (deliberately) taking less substance than prescribed or instructed

Excludes1

  • toxic reaction to local anesthesia in pregnancy (O29.3-)

Excludes2

  • abuse and dependence of psychoactive substances (F10-F19)
  • abuse of non-dependence-producing substances (F55.-)
  • immunodeficiency due to drugs (D84.821)
  • drug reaction and poisoning affecting newborn (P00-P96)
  • pathological drug intoxication (inebriation) (F10-F19)
  1. T45 Poisoning by, adverse effect of and underdosing of primarily systemic and hematological agents, not elsewhere classified

    The appropriate 7th character is to be added to each code from category T45

    • A - initial encounter
    • D - subsequent encounter
    • S - sequela
    1. T45.0 Poisoning by, adverse effect of and underdosing of antiallergic and antiemetic drugs

      1. T45.0X Poisoning by, adverse effect of and underdosing of antiallergic and antiemetic drugs

        • T45.0X1 Poisoning by antiallergic and antiemetic drugs, accidental (unintentional)

          Inclusion term(s):

          • Poisoning by antiallergic and antiemetic drugs NOS
        • T45.0X2 Poisoning by antiallergic and antiemetic drugs, intentional self-harm
        • T45.0X3 Poisoning by antiallergic and antiemetic drugs, assault
        • T45.0X4 Poisoning by antiallergic and antiemetic drugs, undetermined
        • T45.0X5 Adverse effect of antiallergic and antiemetic drugs
        • T45.0X6 Underdosing of antiallergic and antiemetic drugs
    2. T45.1 Poisoning by, adverse effect of and underdosing of antineoplastic and immunosuppressive drugs

      1. T45.1X Poisoning by, adverse effect of and underdosing of antineoplastic and immunosuppressive drugs

        • T45.1X1 Poisoning by antineoplastic and immunosuppressive drugs, accidental (unintentional)

          Inclusion term(s):

          • Poisoning by antineoplastic and immunosuppressive drugs NOS
        • T45.1X2 Poisoning by antineoplastic and immunosuppressive drugs, intentional self-harm
        • T45.1X3 Poisoning by antineoplastic and immunosuppressive drugs, assault
        • T45.1X4 Poisoning by antineoplastic and immunosuppressive drugs, undetermined
        • T45.1X5 Adverse effect of antineoplastic and immunosuppressive drugs
        • T45.1X6 Underdosing of antineoplastic and immunosuppressive drugs
    3. T45.2 Poisoning by, adverse effect of and underdosing of vitamins

      1. T45.2X Poisoning by, adverse effect of and underdosing of vitamins

        • T45.2X1 Poisoning by vitamins, accidental (unintentional)

          Inclusion term(s):

          • Poisoning by vitamins NOS
        • T45.2X2 Poisoning by vitamins, intentional self-harm
        • T45.2X3 Poisoning by vitamins, assault
        • T45.2X4 Poisoning by vitamins, undetermined
        • T45.2X5 Adverse effect of vitamins
        • T45.2X6 Underdosing of vitamins
    4. T45.3 Poisoning by, adverse effect of and underdosing of enzymes

      1. T45.3X Poisoning by, adverse effect of and underdosing of enzymes

    5. T45.4 Poisoning by, adverse effect of and underdosing of iron and its compounds

      1. T45.4X Poisoning by, adverse effect of and underdosing of iron and its compounds

        • T45.4X1 Poisoning by iron and its compounds, accidental (unintentional)

          Inclusion term(s):

          • Poisoning by iron and its compounds NOS
        • T45.4X2 Poisoning by iron and its compounds, intentional self-harm
        • T45.4X3 Poisoning by iron and its compounds, assault
        • T45.4X4 Poisoning by iron and its compounds, undetermined
        • T45.4X5 Adverse effect of iron and its compounds
        • T45.4X6 Underdosing of iron and its compounds
    6. T45.5 Poisoning by, adverse effect of and underdosing of anticoagulants and antithrombotic drugs

      1. T45.51 Poisoning by, adverse effect of and underdosing of anticoagulants

        • T45.511 Poisoning by anticoagulants, accidental (unintentional)

          Inclusion term(s):

          • Poisoning by anticoagulants NOS
        • T45.512 Poisoning by anticoagulants, intentional self-harm
        • T45.513 Poisoning by anticoagulants, assault
        • T45.514 Poisoning by anticoagulants, undetermined
        • T45.515 Adverse effect of anticoagulants
        • T45.516 Underdosing of anticoagulants
      2. T45.52 Poisoning by, adverse effect of and underdosing of antithrombotic drugs

        Inclusion term(s):

        • Poisoning by, adverse effect of and underdosing of antiplatelet drugs
        • T45.521 Poisoning by antithrombotic drugs, accidental (unintentional)

          Inclusion term(s):

          • Poisoning by antithrombotic drug NOS
        • T45.522 Poisoning by antithrombotic drugs, intentional self-harm
        • T45.523 Poisoning by antithrombotic drugs, assault
        • T45.524 Poisoning by antithrombotic drugs, undetermined
        • T45.525 Adverse effect of antithrombotic drugs
        • T45.526 Underdosing of antithrombotic drugs
    7. T45.6 Poisoning by, adverse effect of and underdosing of fibrinolysis-affecting drugs

      1. T45.60 Poisoning by, adverse effect of and underdosing of unspecified fibrinolysis-affecting drugs

        • T45.601 Poisoning by unspecified fibrinolysis-affecting drugs, accidental (unintentional)

          Inclusion term(s):

          • Poisoning by fibrinolysis-affecting drug NOS
        • T45.602 Poisoning by unspecified fibrinolysis-affecting drugs, intentional self-harm
        • T45.603 Poisoning by unspecified fibrinolysis-affecting drugs, assault
        • T45.604 Poisoning by unspecified fibrinolysis-affecting drugs, undetermined
        • T45.605 Adverse effect of unspecified fibrinolysis-affecting drugs
        • T45.606 Underdosing of unspecified fibrinolysis-affecting drugs
      2. T45.61 Poisoning by, adverse effect of and underdosing of thrombolytic drugs

        • T45.611 Poisoning by thrombolytic drug, accidental (unintentional)

          Inclusion term(s):

          • Poisoning by thrombolytic drug NOS
        • T45.612 Poisoning by thrombolytic drug, intentional self-harm
        • T45.613 Poisoning by thrombolytic drug, assault
        • T45.614 Poisoning by thrombolytic drug, undetermined
        • T45.615 Adverse effect of thrombolytic drugs
        • T45.616 Underdosing of thrombolytic drugs
      3. T45.62 Poisoning by, adverse effect of and underdosing of hemostatic drugs

        • T45.621 Poisoning by hemostatic drug, accidental (unintentional)

          Inclusion term(s):

          • Poisoning by hemostatic drug NOS
        • T45.622 Poisoning by hemostatic drug, intentional self-harm
        • T45.623 Poisoning by hemostatic drug, assault
        • T45.624 Poisoning by hemostatic drug, undetermined
        • T45.625 Adverse effect of hemostatic drug
        • T45.626 Underdosing of hemostatic drugs
      4. T45.69 Poisoning by, adverse effect of and underdosing of other fibrinolysis-affecting drugs

        • T45.691 Poisoning by other fibrinolysis-affecting drugs, accidental (unintentional)

          Inclusion term(s):

          • Poisoning by other fibrinolysis-affecting drug NOS
        • T45.692 Poisoning by other fibrinolysis-affecting drugs, intentional self-harm
        • T45.693 Poisoning by other fibrinolysis-affecting drugs, assault
        • T45.694 Poisoning by other fibrinolysis-affecting drugs, undetermined
        • T45.695 Adverse effect of other fibrinolysis-affecting drugs
        • T45.696 Underdosing of other fibrinolysis-affecting drugs
    8. T45.7 Poisoning by, adverse effect of and underdosing of anticoagulant antagonists, vitamin K and other coagulants

      1. T45.7X Poisoning by, adverse effect of and underdosing of anticoagulant antagonists, vitamin K and other coagulants

        • T45.7X1 Poisoning by anticoagulant antagonists, vitamin K and other coagulants, accidental (unintentional)

          Inclusion term(s):

          • Poisoning by anticoagulant antagonists, vitamin K and other coagulants NOS
        • T45.7X2 Poisoning by anticoagulant antagonists, vitamin K and other coagulants, intentional self-harm
        • T45.7X3 Poisoning by anticoagulant antagonists, vitamin K and other coagulants, assault
        • T45.7X4 Poisoning by anticoagulant antagonists, vitamin K and other coagulants, undetermined
        • T45.7X5 Adverse effect of anticoagulant antagonists, vitamin K and other coagulants
        • T45.7X6 Underdosing of anticoagulant antagonist, vitamin K and other coagulants
    9. T45.8 Poisoning by, adverse effect of and underdosing of other primarily systemic and hematological agents

      Inclusion term(s):

      • Poisoning by, adverse effect of and underdosing of liver preparations and other antianemic agents
      • Poisoning by, adverse effect of and underdosing of natural blood and blood products
      • Poisoning by, adverse effect of and underdosing of plasma substitute
      1. T45.8X Poisoning by, adverse effect of and underdosing of other primarily systemic and hematological agents

        • T45.8X1 Poisoning by other primarily systemic and hematological agents, accidental (unintentional)

          Inclusion term(s):

          • Poisoning by other primarily systemic and hematological agents NOS
        • T45.8X2 Poisoning by other primarily systemic and hematological agents, intentional self-harm
        • T45.8X3 Poisoning by other primarily systemic and hematological agents, assault
        • T45.8X4 Poisoning by other primarily systemic and hematological agents, undetermined
        • T45.8X5 Adverse effect of other primarily systemic and hematological agents
        • T45.8X6 Underdosing of other primarily systemic and hematological agents
    10. T45.9 Poisoning by, adverse effect of and underdosing of unspecified primarily systemic and hematological agent

      1. T45.91 Poisoning by unspecified primarily systemic and hematological agent, accidental (unintentional)

        Inclusion term(s):

        • Poisoning by primarily systemic and hematological agent NOS
      2. T45.92 Poisoning by unspecified primarily systemic and hematological agent, intentional self-harm

      3. T45.93 Poisoning by unspecified primarily systemic and hematological agent, assault

      4. T45.94 Poisoning by unspecified primarily systemic and hematological agent, undetermined

      5. T45.95 Adverse effect of unspecified primarily systemic and hematological agent

      6. T45.96 Underdosing of unspecified primarily systemic and hematological agent

Abbreviations used here:

NEC Not elsewhere classifiable
This abbreviation in the Tabular List represents “other specified”. When a specific code is not available for a condition, the Tabular List includes an NEC entry under a code to identify the code as the “other specified” code.

NOS Not otherwise specified
This abbreviation is the equivalent of unspecified.