The drug giving rise to the adverse effect should be identified by use of codes from categories T36-T50 with fifth or sixth character 5.

Use additional code(s) to specify:
manifestations of poisoning
underdosing or failure in dosage during medical and surgical care (Y63.6, Y63.8-Y63.9)
underdosing of medication regimen (Z91.12-, Z91.13-)

Code first  , for adverse effects, the nature of the adverse effect, such as:
  adverse effect NOS (T88.7)
  aspirin gastritis (K29.-)
  blood disorders (D56-D76)
  contact dermatitis (L23-L25)
  dermatitis due to substances taken internally (L27.-)
  nephropathy (N14.0-N14.2)

Includes:

  • adverse effect of correct substance properly administered
  • poisoning by overdose of substance
  • poisoning by wrong substance given or taken in error
  • underdosing by (inadvertently) (deliberately) taking less substance than prescribed or instructed

Excludes1

  • toxic reaction to local anesthesia in pregnancy (O29.3-)

Excludes2

  • abuse and dependence of psychoactive substances (F10-F19)
  • abuse of non-dependence-producing substances (F55.-)
  • immunodeficiency due to drugs (D84.821)
  • drug reaction and poisoning affecting newborn (P00-P96)
  • pathological drug intoxication (inebriation) (F10-F19)
  1. T46 Poisoning by, adverse effect of and underdosing of agents primarily affecting the cardiovascular system

    1. T46.0 Poisoning by, adverse effect of and underdosing of cardiac-stimulant glycosides and drugs of similar action

      1. T46.0X Poisoning by, adverse effect of and underdosing of cardiac-stimulant glycosides and drugs of similar action

        • T46.0X1 Poisoning by cardiac-stimulant glycosides and drugs of similar action, accidental (unintentional)

          Inclusion term(s):

          • Poisoning by cardiac-stimulant glycosides and drugs of similar action NOS
        • T46.0X2 Poisoning by cardiac-stimulant glycosides and drugs of similar action, intentional self-harm
        • T46.0X3 Poisoning by cardiac-stimulant glycosides and drugs of similar action, assault
        • T46.0X4 Poisoning by cardiac-stimulant glycosides and drugs of similar action, undetermined
        • T46.0X5 Adverse effect of cardiac-stimulant glycosides and drugs of similar action
        • T46.0X6 Underdosing of cardiac-stimulant glycosides and drugs of similar action
    2. T46.1 Poisoning by, adverse effect of and underdosing of calcium-channel blockers

      1. T46.1X Poisoning by, adverse effect of and underdosing of calcium-channel blockers

        • T46.1X1 Poisoning by calcium-channel blockers, accidental (unintentional)

          Inclusion term(s):

          • Poisoning by calcium-channel blockers NOS
        • T46.1X2 Poisoning by calcium-channel blockers, intentional self-harm
        • T46.1X3 Poisoning by calcium-channel blockers, assault
        • T46.1X4 Poisoning by calcium-channel blockers, undetermined
        • T46.1X5 Adverse effect of calcium-channel blockers
        • T46.1X6 Underdosing of calcium-channel blockers
    3. T46.2 Poisoning by, adverse effect of and underdosing of other antidysrhythmic drugs, not elsewhere classified

      1. T46.2X Poisoning by, adverse effect of and underdosing of other antidysrhythmic drugs

        • T46.2X1 Poisoning by other antidysrhythmic drugs, accidental (unintentional)

          Inclusion term(s):

          • Poisoning by other antidysrhythmic drugs NOS
        • T46.2X2 Poisoning by other antidysrhythmic drugs, intentional self-harm
        • T46.2X3 Poisoning by other antidysrhythmic drugs, assault
        • T46.2X4 Poisoning by other antidysrhythmic drugs, undetermined
        • T46.2X5 Adverse effect of other antidysrhythmic drugs
        • T46.2X6 Underdosing of other antidysrhythmic drugs
    4. T46.3 Poisoning by, adverse effect of and underdosing of coronary vasodilators

      Inclusion term(s):

      • Poisoning by, adverse effect of and underdosing of dipyridamole
      1. T46.3X Poisoning by, adverse effect of and underdosing of coronary vasodilators

        • T46.3X1 Poisoning by coronary vasodilators, accidental (unintentional)

          Inclusion term(s):

          • Poisoning by coronary vasodilators NOS
        • T46.3X2 Poisoning by coronary vasodilators, intentional self-harm
        • T46.3X3 Poisoning by coronary vasodilators, assault
        • T46.3X4 Poisoning by coronary vasodilators, undetermined
        • T46.3X5 Adverse effect of coronary vasodilators
        • T46.3X6 Underdosing of coronary vasodilators
    5. T46.4 Poisoning by, adverse effect of and underdosing of angiotensin-converting-enzyme inhibitors

      1. T46.4X Poisoning by, adverse effect of and underdosing of angiotensin-converting-enzyme inhibitors

        • T46.4X1 Poisoning by angiotensin-converting-enzyme inhibitors, accidental (unintentional)

          Inclusion term(s):

          • Poisoning by angiotensin-converting-enzyme inhibitors NOS
        • T46.4X2 Poisoning by angiotensin-converting-enzyme inhibitors, intentional self-harm
        • T46.4X3 Poisoning by angiotensin-converting-enzyme inhibitors, assault
        • T46.4X4 Poisoning by angiotensin-converting-enzyme inhibitors, undetermined
        • T46.4X5 Adverse effect of angiotensin-converting-enzyme inhibitors
        • T46.4X6 Underdosing of angiotensin-converting-enzyme inhibitors
    6. T46.5 Poisoning by, adverse effect of and underdosing of other antihypertensive drugs

      1. T46.5X Poisoning by, adverse effect of and underdosing of other antihypertensive drugs

        • T46.5X1 Poisoning by other antihypertensive drugs, accidental (unintentional)

          Inclusion term(s):

          • Poisoning by other antihypertensive drugs NOS
        • T46.5X2 Poisoning by other antihypertensive drugs, intentional self-harm
        • T46.5X3 Poisoning by other antihypertensive drugs, assault
        • T46.5X4 Poisoning by other antihypertensive drugs, undetermined
        • T46.5X5 Adverse effect of other antihypertensive drugs
        • T46.5X6 Underdosing of other antihypertensive drugs
    7. T46.6 Poisoning by, adverse effect of and underdosing of antihyperlipidemic and antiarteriosclerotic drugs

      1. T46.6X Poisoning by, adverse effect of and underdosing of antihyperlipidemic and antiarteriosclerotic drugs

        • T46.6X1 Poisoning by antihyperlipidemic and antiarteriosclerotic drugs, accidental (unintentional)

          Inclusion term(s):

          • Poisoning by antihyperlipidemic and antiarteriosclerotic drugs NOS
        • T46.6X2 Poisoning by antihyperlipidemic and antiarteriosclerotic drugs, intentional self-harm
        • T46.6X3 Poisoning by antihyperlipidemic and antiarteriosclerotic drugs, assault
        • T46.6X4 Poisoning by antihyperlipidemic and antiarteriosclerotic drugs, undetermined
        • T46.6X5 Adverse effect of antihyperlipidemic and antiarteriosclerotic drugs
        • T46.6X6 Underdosing of antihyperlipidemic and antiarteriosclerotic drugs
    8. T46.7 Poisoning by, adverse effect of and underdosing of peripheral vasodilators

      Inclusion term(s):

      • Poisoning by, adverse effect of and underdosing of nicotinic acid (derivatives)
      1. T46.7X Poisoning by, adverse effect of and underdosing of peripheral vasodilators

        • T46.7X1 Poisoning by peripheral vasodilators, accidental (unintentional)

          Inclusion term(s):

          • Poisoning by peripheral vasodilators NOS
        • T46.7X2 Poisoning by peripheral vasodilators, intentional self-harm
        • T46.7X3 Poisoning by peripheral vasodilators, assault
        • T46.7X4 Poisoning by peripheral vasodilators, undetermined
        • T46.7X5 Adverse effect of peripheral vasodilators
        • T46.7X6 Underdosing of peripheral vasodilators
    9. T46.8 Poisoning by, adverse effect of and underdosing of antivaricose drugs, including sclerosing agents

      1. T46.8X Poisoning by, adverse effect of and underdosing of antivaricose drugs, including sclerosing agents

        • T46.8X1 Poisoning by antivaricose drugs, including sclerosing agents, accidental (unintentional)

          Inclusion term(s):

          • Poisoning by antivaricose drugs, including sclerosing agents NOS
        • T46.8X2 Poisoning by antivaricose drugs, including sclerosing agents, intentional self-harm
        • T46.8X3 Poisoning by antivaricose drugs, including sclerosing agents, assault
        • T46.8X4 Poisoning by antivaricose drugs, including sclerosing agents, undetermined
        • T46.8X5 Adverse effect of antivaricose drugs, including sclerosing agents
        • T46.8X6 Underdosing of antivaricose drugs, including sclerosing agents
    10. T46.9 Poisoning by, adverse effect of and underdosing of other and unspecified agents primarily affecting the cardiovascular system

      1. T46.90 Poisoning by, adverse effect of and underdosing of unspecified agents primarily affecting the cardiovascular system

        • T46.901 Poisoning by unspecified agents primarily affecting the cardiovascular system, accidental (unintentional)
        • T46.902 Poisoning by unspecified agents primarily affecting the cardiovascular system, intentional self-harm
        • T46.903 Poisoning by unspecified agents primarily affecting the cardiovascular system, assault
        • T46.904 Poisoning by unspecified agents primarily affecting the cardiovascular system, undetermined
        • T46.905 Adverse effect of unspecified agents primarily affecting the cardiovascular system
        • T46.906 Underdosing of unspecified agents primarily affecting the cardiovascular system
      2. T46.99 Poisoning by, adverse effect of and underdosing of other agents primarily affecting the cardiovascular system

        • T46.991 Poisoning by other agents primarily affecting the cardiovascular system, accidental (unintentional)
        • T46.992 Poisoning by other agents primarily affecting the cardiovascular system, intentional self-harm
        • T46.993 Poisoning by other agents primarily affecting the cardiovascular system, assault
        • T46.994 Poisoning by other agents primarily affecting the cardiovascular system, undetermined
        • T46.995 Adverse effect of other agents primarily affecting the cardiovascular system
        • T46.996 Underdosing of other agents primarily affecting the cardiovascular system
Abbreviations used here:

NEC Not elsewhere classifiable
This abbreviation in the Tabular List represents “other specified”. When a specific code is not available for a condition, the Tabular List includes an NEC entry under a code to identify the code as the “other specified” code.

NOS Not otherwise specified
This abbreviation is the equivalent of unspecified.