The drug giving rise to the adverse effect should be identified by use of codes from categories T36-T50 with fifth or sixth character 5.

Use Additional code(s) to specify:
manifestations of poisoning
underdosing or failure in dosage during medical and surgical care (Y63.6, Y63.8-Y63.9)
underdosing of medication regimen (Z91.12-, Z91.13-)

Code first   , for adverse effects, the nature of the adverse effect, such as:
  adverse effect NOS (T88.7)
  aspirin gastritis (K29.-)
  blood disorders (D56-D76)
  contact dermatitis (L23-L25)
  dermatitis due to substances taken internally (L27.-)
  nephropathy (N14.0-N14.2)

Includes:

  • adverse effect of correct substance properly administered
  • poisoning by overdose of substance
  • poisoning by wrong substance given or taken in error
  • underdosing by (inadvertently) (deliberately) taking less substance than prescribed or instructed

Excludes1

  • toxic reaction to local anesthesia in pregnancy (O29.3-)

Excludes2

  • abuse and dependence of psychoactive substances (F10-F19)
  • abuse of non-dependence-producing substances (F55.-)
  • drug reaction and poisoning affecting newborn (P00-P96)
  • pathological drug intoxication (inebriation) (F10-F19)
  1. T49 Poisoning by, adverse effect of and underdosing of topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinorlaryngological and dental drugs

    Includes:

    • poisoning by, adverse effect of and underdosing of glucocorticoids, topically used

    The appropriate 7th character is to be added to each code from category T49

    • A - initial encounter
    • D - subsequent encounter
    • S - sequela
    1. T49.0 Poisoning by, adverse effect of and underdosing of local antifungal, anti-infective and anti-inflammatory drugs

      1. T49.0X Poisoning by, adverse effect of and underdosing of local antifungal, anti-infective and anti-inflammatory drugs

        • T49.0X1 Poisoning by local antifungal, anti-infective and anti-inflammatory drugs, accidental (unintentional)

          Inclusion term(s):

          • Poisoning by local antifungal, anti-infective and anti-inflammatory drugs NOS
        • T49.0X2 Poisoning by local antifungal, anti-infective and anti-inflammatory drugs, intentional self-harm
        • T49.0X3 Poisoning by local antifungal, anti-infective and anti-inflammatory drugs, assault
        • T49.0X4 Poisoning by local antifungal, anti-infective and anti-inflammatory drugs, undetermined
        • T49.0X5 Adverse effect of local antifungal, anti-infective and anti-inflammatory drugs
        • T49.0X6 Underdosing of local antifungal, anti-infective and anti-inflammatory drugs
    2. T49.1 Poisoning by, adverse effect of and underdosing of antipruritics

      1. T49.1X Poisoning by, adverse effect of and underdosing of antipruritics

        • T49.1X1 Poisoning by antipruritics, accidental (unintentional)

          Inclusion term(s):

          • Poisoning by antipruritics NOS
        • T49.1X2 Poisoning by antipruritics, intentional self-harm
        • T49.1X3 Poisoning by antipruritics, assault
        • T49.1X4 Poisoning by antipruritics, undetermined
        • T49.1X5 Adverse effect of antipruritics
        • T49.1X6 Underdosing of antipruritics
    3. T49.2 Poisoning by, adverse effect of and underdosing of local astringents and local detergents

      1. T49.2X Poisoning by, adverse effect of and underdosing of local astringents and local detergents

        • T49.2X1 Poisoning by local astringents and local detergents, accidental (unintentional)

          Inclusion term(s):

          • Poisoning by local astringents and local detergents NOS
        • T49.2X2 Poisoning by local astringents and local detergents, intentional self-harm
        • T49.2X3 Poisoning by local astringents and local detergents, assault
        • T49.2X4 Poisoning by local astringents and local detergents, undetermined
        • T49.2X5 Adverse effect of local astringents and local detergents
        • T49.2X6 Underdosing of local astringents and local detergents
    4. T49.3 Poisoning by, adverse effect of and underdosing of emollients, demulcents and protectants

      1. T49.3X Poisoning by, adverse effect of and underdosing of emollients, demulcents and protectants

        • T49.3X1 Poisoning by emollients, demulcents and protectants, accidental (unintentional)

          Inclusion term(s):

          • Poisoning by emollients, demulcents and protectants NOS
        • T49.3X2 Poisoning by emollients, demulcents and protectants, intentional self-harm
        • T49.3X3 Poisoning by emollients, demulcents and protectants, assault
        • T49.3X4 Poisoning by emollients, demulcents and protectants, undetermined
        • T49.3X5 Adverse effect of emollients, demulcents and protectants
        • T49.3X6 Underdosing of emollients, demulcents and protectants
    5. T49.4 Poisoning by, adverse effect of and underdosing of keratolytics, keratoplastics, and other hair treatment drugs and preparations

      1. T49.4X Poisoning by, adverse effect of and underdosing of keratolytics, keratoplastics, and other hair treatment drugs and preparations

        • T49.4X1 Poisoning by keratolytics, keratoplastics, and other hair treatment drugs and preparations, accidental (unintentional)

          Inclusion term(s):

          • Poisoning by keratolytics, keratoplastics, and other hair treatment drugs and preparations NOS
        • T49.4X2 Poisoning by keratolytics, keratoplastics, and other hair treatment drugs and preparations, intentional self-harm
        • T49.4X3 Poisoning by keratolytics, keratoplastics, and other hair treatment drugs and preparations, assault
        • T49.4X4 Poisoning by keratolytics, keratoplastics, and other hair treatment drugs and preparations, undetermined
        • T49.4X5 Adverse effect of keratolytics, keratoplastics, and other hair treatment drugs and preparations
        • T49.4X6 Underdosing of keratolytics, keratoplastics, and other hair treatment drugs and preparations
    6. T49.5 Poisoning by, adverse effect of and underdosing of ophthalmological drugs and preparations

      1. T49.5X Poisoning by, adverse effect of and underdosing of ophthalmological drugs and preparations

        • T49.5X1 Poisoning by ophthalmological drugs and preparations, accidental (unintentional)

          Inclusion term(s):

          • Poisoning by ophthalmological drugs and preparations NOS
        • T49.5X2 Poisoning by ophthalmological drugs and preparations, intentional self-harm
        • T49.5X3 Poisoning by ophthalmological drugs and preparations, assault
        • T49.5X4 Poisoning by ophthalmological drugs and preparations, undetermined
        • T49.5X5 Adverse effect of ophthalmological drugs and preparations
        • T49.5X6 Underdosing of ophthalmological drugs and preparations
    7. T49.6 Poisoning by, adverse effect of and underdosing of otorhinolaryngological drugs and preparations

      1. T49.6X Poisoning by, adverse effect of and underdosing of otorhinolaryngological drugs and preparations

        • T49.6X1 Poisoning by otorhinolaryngological drugs and preparations, accidental (unintentional)

          Inclusion term(s):

          • Poisoning by otorhinolaryngological drugs and preparations NOS
        • T49.6X2 Poisoning by otorhinolaryngological drugs and preparations, intentional self-harm
        • T49.6X3 Poisoning by otorhinolaryngological drugs and preparations, assault
        • T49.6X4 Poisoning by otorhinolaryngological drugs and preparations, undetermined
        • T49.6X5 Adverse effect of otorhinolaryngological drugs and preparations
        • T49.6X6 Underdosing of otorhinolaryngological drugs and preparations
    8. T49.7 Poisoning by, adverse effect of and underdosing of dental drugs, topically applied

      1. T49.7X Poisoning by, adverse effect of and underdosing of dental drugs, topically applied

        • T49.7X1 Poisoning by dental drugs, topically applied, accidental (unintentional)

          Inclusion term(s):

          • Poisoning by dental drugs, topically applied NOS
        • T49.7X2 Poisoning by dental drugs, topically applied, intentional self-harm
        • T49.7X3 Poisoning by dental drugs, topically applied, assault
        • T49.7X4 Poisoning by dental drugs, topically applied, undetermined
        • T49.7X5 Adverse effect of dental drugs, topically applied
        • T49.7X6 Underdosing of dental drugs, topically applied
    9. T49.8 Poisoning by, adverse effect of and underdosing of other topical agents

      Inclusion term(s):

      • Poisoning by, adverse effect of and underdosing of spermicides
      1. T49.8X Poisoning by, adverse effect of and underdosing of other topical agents

        • T49.8X1 Poisoning by other topical agents, accidental (unintentional)

          Inclusion term(s):

          • Poisoning by other topical agents NOS
        • T49.8X2 Poisoning by other topical agents, intentional self-harm
        • T49.8X3 Poisoning by other topical agents, assault
        • T49.8X4 Poisoning by other topical agents, undetermined
        • T49.8X5 Adverse effect of other topical agents
        • T49.8X6 Underdosing of other topical agents
    10. T49.9 Poisoning by, adverse effect of and underdosing of unspecified topical agent

      1. T49.91 Poisoning by unspecified topical agent, accidental (unintentional)

      2. T49.92 Poisoning by unspecified topical agent, intentional self-harm

      3. T49.93 Poisoning by unspecified topical agent, assault

      4. T49.94 Poisoning by unspecified topical agent, undetermined

      5. T49.95 Adverse effect of unspecified topical agent

      6. T49.96 Underdosing of unspecified topical agent

Abbreviations used here:

NEC Not elsewhere classifiable
This abbreviation in the Tabular List represents “other specified”. When a specific code is not available for a condition, the Tabular List includes an NEC entry under a code to identify the code as the “other specified” code.

NOS Not otherwise specified
This abbreviation is the equivalent of unspecified.