Use additional code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)
code(s) to identify the specified condition resulting from the complication
code to identify devices involved and details of circumstances (Y62-Y82)

Excludes2

  • any encounters with medical care for postprocedural conditions in which no complications are present, such as:
  • artificial opening status (Z93.-)
  • closure of external stoma (Z43.-)
  • fitting and adjustment of external prosthetic device (Z44.-)
  • burns and corrosions from local applications and irradiation (T20-T32)
  • complications of surgical procedures during pregnancy, childbirth and the puerperium (O00-O9A)
  • mechanical complication of respirator [ventilator] (J95.850)
  • poisoning and toxic effects of drugs and chemicals (T36-T65 with fifth or sixth character 1-4 or 6)
  • postprocedural fever (R50.82)
  • specified complications classified elsewhere, such as:
  • cerebrospinal fluid leak from spinal puncture (G97.0)
  • colostomy malfunction (K94.0-)
  • disorders of fluid and electrolyte imbalance (E86-E87)
  • functional disturbances following cardiac surgery (I97.0-I97.1)
  • intraoperative and postprocedural complications of specified body systems (D78.-, E36.-, E89.-, G97.3-, G97.4, H59.3-, H59.-, H95.2-, H95.3, I97.4-, I97.5, J95.6-, J95.7, K91.6-, L76.-, M96.-, N99.-)
  • ostomy complications (J95.0-, K94.-, N99.5-)
  • postgastric surgery syndromes (K91.1)
  • postlaminectomy syndrome NEC (M96.1)
  • postmastectomy lymphedema syndrome (I97.2)
  • postsurgical blind-loop syndrome (K91.2)
  • ventilator associated pneumonia (J95.851)
  1. T80 Complications following infusion, transfusion and therapeutic injection

    Includes:

    • complications following perfusion

    Excludes2

    • bone marrow transplant rejection (T86.01)
    • febrile nonhemolytic transfusion reaction (R50.84)
    • fluid overload due to transfusion (E87.71)
    • posttransfusion purpura (D69.51)
    • transfusion associated circulatory overload (TACO) (E87.71)
    • transfusion (red blood cell) associated hemochromatosis (E83.111)
    • transfusion related acute lung injury (TRALI) (J95.84)

    The appropriate 7th character is to be added to each code from category T80

    • A - initial encounter
    • D - subsequent encounter
    • S - sequela
    1. T80.0 Air embolism following infusion, transfusion and therapeutic injection

    2. T80.1 Vascular complications following infusion, transfusion and therapeutic injection

    3. T80.2 Infections following infusion, transfusion and therapeutic injection

      1. T80.21 Infection due to central venous catheter

        Inclusion term(s):

        • Infection due to pulmonary artery catheter (Swan-Ganz catheter)
        • T80.211 Bloodstream infection due to central venous catheter

          Inclusion term(s):

          • Catheter-related bloodstream infection (CRBSI) NOS
          • Central line-associated bloodstream infection (CLABSI)
          • Bloodstream infection due to Hickman catheter
          • Bloodstream infection due to peripherally inserted central catheter (PICC)
          • Bloodstream infection due to portacath (port-a-cath)
          • Bloodstream infection due to pulmonary artery catheter
          • Bloodstream infection due to triple lumen catheter
          • Bloodstream infection due to umbilical venous catheter
        • T80.212 Local infection due to central venous catheter

          Inclusion term(s):

          • Exit or insertion site infection
          • Local infection due to Hickman catheter
          • Local infection due to peripherally inserted central catheter (PICC)
          • Local infection due to portacath (port-a-cath)
          • Local infection due to pulmonary artery catheter
          • Local infection due to triple lumen catheter
          • Local infection due to umbilical venous catheter
          • Port or reservoir infection
          • Tunnel infection
        • T80.218 Other infection due to central venous catheter

          Inclusion term(s):

          • Other central line-associated infection
          • Other infection due to Hickman catheter
          • Other infection due to peripherally inserted central catheter (PICC)
          • Other infection due to portacath (port-a-cath)
          • Other infection due to pulmonary artery catheter
          • Other infection due to triple lumen catheter
          • Other infection due to umbilical venous catheter
        • T80.219 Unspecified infection due to central venous catheter

          Inclusion term(s):

          • Central line-associated infection NOS
          • Unspecified infection due to Hickman catheter
          • Unspecified infection due to peripherally inserted central catheter (PICC)
          • Unspecified infection due to portacath (port-a-cath)
          • Unspecified infection due to pulmonary artery catheter
          • Unspecified infection due to triple lumen catheter
          • Unspecified infection due to umbilical venous catheter
      2. T80.22 Acute infection following transfusion, infusion, or injection of blood and blood products

      3. T80.29 Infection following other infusion, transfusion and therapeutic injection

    4. T80.3 ABO incompatibility reaction due to transfusion of blood or blood products

      1. T80.30 ABO incompatibility reaction due to transfusion of blood or blood products, unspecified

        Inclusion term(s):

        • ABO incompatibility blood transfusion NOS
        • Reaction to ABO incompatibility from transfusion NOS
      2. T80.31 ABO incompatibility with hemolytic transfusion reaction

        • T80.310 ABO incompatibility with acute hemolytic transfusion reaction

          Inclusion term(s):

          • ABO incompatibility with hemolytic transfusion reaction less than 24 hours after transfusion
          • Acute hemolytic transfusion reaction (AHTR) due to ABO incompatibility
        • T80.311 ABO incompatibility with delayed hemolytic transfusion reaction

          Inclusion term(s):

          • ABO incompatibility with hemolytic transfusion reaction 24 hours or more after transfusion
          • Delayed hemolytic transfusion reaction (DHTR) due to ABO incompatibility
        • T80.319 ABO incompatibility with hemolytic transfusion reaction, unspecified

          Inclusion term(s):

          • ABO incompatibility with hemolytic transfusion reaction at unspecified time after transfusion
          • Hemolytic transfusion reaction (HTR) due to ABO incompatibility NOS
      3. T80.39 Other ABO incompatibility reaction due to transfusion of blood or blood products

        Inclusion term(s):

        • Delayed serologic transfusion reaction (DSTR) from ABO incompatibility
        • Other ABO incompatible blood transfusion
        • Other reaction to ABO incompatible blood transfusion
    5. T80.4 Rh incompatibility reaction due to transfusion of blood or blood products

      Inclusion term(s):

      • Reaction due to incompatibility of Rh antigens (C) (c) (D) (E) (e)
      1. T80.40 Rh incompatibility reaction due to transfusion of blood or blood products, unspecified

        Inclusion term(s):

        • Reaction due to Rh factor in transfusion NOS
        • Rh incompatible blood transfusion NOS
      2. T80.41 Rh incompatibility with hemolytic transfusion reaction

        • T80.410 Rh incompatibility with acute hemolytic transfusion reaction

          Inclusion term(s):

          • Acute hemolytic transfusion reaction (AHTR) due to Rh incompatibility
          • Rh incompatibility with hemolytic transfusion reaction less than 24 hours after transfusion
        • T80.411 Rh incompatibility with delayed hemolytic transfusion reaction

          Inclusion term(s):

          • Delayed hemolytic transfusion reaction (DHTR) due to Rh incompatibility
          • Rh incompatibility with hemolytic transfusion reaction 24 hours or more after transfusion
        • T80.419 Rh incompatibility with hemolytic transfusion reaction, unspecified

          Inclusion term(s):

          • Rh incompatibility with hemolytic transfusion reaction at unspecified time after transfusion
          • Hemolytic transfusion reaction (HTR) due to Rh incompatibility NOS
      3. T80.49 Other Rh incompatibility reaction due to transfusion of blood or blood products

        Inclusion term(s):

        • Delayed serologic transfusion reaction (DSTR) from Rh incompatibility
        • Other reaction to Rh incompatible blood transfusion
    6. T80.5 Anaphylactic reaction due to serum

      Inclusion term(s):

      • Allergic shock due to serum
      • Anaphylactic shock due to serum
      • Anaphylactoid reaction due to serum
      • Anaphylaxis due to serum
      1. T80.51 Anaphylactic reaction due to administration of blood and blood products

      2. T80.52 Anaphylactic reaction due to vaccination

      3. T80.59 Anaphylactic reaction due to other serum

    7. T80.6 Other serum reactions

      Inclusion term(s):

      • Intoxication by serum
      • Protein sickness
      • Serum rash
      • Serum sickness
      • Serum urticaria
      1. T80.61 Other serum reaction due to administration of blood and blood products

      2. T80.62 Other serum reaction due to vaccination

      3. T80.69 Other serum reaction due to other serum

    8. T80.8 Other complications following infusion, transfusion and therapeutic injection

      1. T80.81 Extravasation of vesicant agent

        Inclusion term(s):

        • Infiltration of vesicant agent
      2. T80.82 Complication of immune effector cellular therapy

        Inclusion term(s):

        • Complication of chimeric antigen receptor (CAR-T) cell therapy
        • Complication of IEC therapy
      3. T80.89 Other complications following infusion, transfusion and therapeutic injection

        Inclusion term(s):

        • Delayed serologic transfusion reaction (DSTR), unspecified incompatibility
    9. T80.9 Unspecified complication following infusion, transfusion and therapeutic injection

      1. T80.90 Unspecified complication following infusion and therapeutic injection

      2. T80.91 Hemolytic transfusion reaction, unspecified incompatibility

        • T80.910 Acute hemolytic transfusion reaction, unspecified incompatibility
        • T80.911 Delayed hemolytic transfusion reaction, unspecified incompatibility
        • T80.919 Hemolytic transfusion reaction, unspecified incompatibility, unspecified as acute or delayed

          Inclusion term(s):

          • Hemolytic transfusion reaction NOS
      3. T80.92 Unspecified transfusion reaction

        Inclusion term(s):

        • Transfusion reaction NOS
    10. T80.A Non-ABO incompatibility reaction due to transfusion of blood or blood products

      Inclusion term(s):

      • Reaction due to incompatibility of minor antigens (Duffy) (Kell) (Kidd) (Lewis) (M) (N) (P) (S)
      1. T80.A0 Non-ABO incompatibility reaction due to transfusion of blood or blood products, unspecified

        Inclusion term(s):

        • Non-ABO antigen incompatibility reaction from transfusion NOS
      2. T80.A1 Non-ABO incompatibility with hemolytic transfusion reaction

        • T80.A10 Non-ABO incompatibility with acute hemolytic transfusion reaction

          Inclusion term(s):

          • Acute hemolytic transfusion reaction (AHTR) due to non-ABO incompatibility
          • Non-ABO incompatibility with hemolytic transfusion reaction less than 24 hours after transfusion
        • T80.A11 Non-ABO incompatibility with delayed hemolytic transfusion reaction

          Inclusion term(s):

          • Delayed hemolytic transfusion reaction (DHTR) due to non-ABO incompatibility
          • Non-ABO incompatibility with hemolytic transfusion reaction 24 or more hours after transfusion
        • T80.A19 Non-ABO incompatibility with hemolytic transfusion reaction, unspecified

          Inclusion term(s):

          • Hemolytic transfusion reaction (HTR) due to non-ABO incompatibility NOS
          • Non-ABO incompatibility with hemolytic transfusion reaction at unspecified time after transfusion
      3. T80.A9 Other non-ABO incompatibility reaction due to transfusion of blood or blood products

        Inclusion term(s):

        • Delayed serologic transfusion reaction (DSTR) from non-ABO incompatibility
        • Other reaction to non-ABO incompatible blood transfusion
Abbreviations used here:

NEC Not elsewhere classifiable
This abbreviation in the Tabular List represents “other specified”. When a specific code is not available for a condition, the Tabular List includes an NEC entry under a code to identify the code as the “other specified” code.

NOS Not otherwise specified
This abbreviation is the equivalent of unspecified.