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Substance Poisoning
Accidental (unintentional)
Poisoning
Intentional (self-harm)
Poisoning
Assault
Poisoning
Undetermined
Adverse
Effect
Underdosing
Acetazolamide T50.2X1 T50.2X2 T50.2X3 T50.2X4 T50.2X5 T50.2X6
Acetiamine T45.2X1 T45.2X2 T45.2X3 T45.2X4 T45.2X5 T45.2X6
Acetic
– acid T54.2X1 T54.2X2 T54.2X3 T54.2X4 -- --
– – with sodium acetate (ointment) T49.3X1 T49.3X2 T49.3X3 T49.3X4 T49.3X5 T49.3X6
– – ester (solvent)(vapor) T52.8X1 T52.8X2 T52.8X3 T52.8X4 -- --
– – irrigating solution T50.3X1 T50.3X2 T50.3X3 T50.3X4 T50.3X5 T50.3X6
– – medicinal (lotion) T49.2X1 T49.2X2 T49.2X3 T49.2X4 T49.2X5 T49.2X6
– anhydride T65.891 T65.892 T65.893 T65.894 -- --
– ether (vapor) T52.8X1 T52.8X2 T52.8X3 T52.8X4 -- --
Acetohexamide T38.3X1 T38.3X2 T38.3X3 T38.3X4 T38.3X5 T38.3X6
Acetohydroxamic acid T50.991 T50.992 T50.993 T50.994 T50.995 T50.996
Acetomenaphthone T45.7X1 T45.7X2 T45.7X3 T45.7X4 T45.7X5 T45.7X6
Acetomorphine T40.1X1 T40.1X2 T40.1X3 T40.1X4 -- --
Acetone (oils) T52.4X1 T52.4X2 T52.4X3 T52.4X4 -- --
– chlorinated T52.4X1 T52.4X2 T52.4X3 T52.4X4 -- --
– vapor T52.4X1 T52.4X2 T52.4X3 T52.4X4 -- --
Acetonitrile T52.8X1 T52.8X2 T52.8X3 T52.8X4 -- --
Acetophenazine T43.3X1 T43.3X2 T43.3X3 T43.3X4 T43.3X5 T43.3X6

The occurrence of drug toxicity is classified in ICD-10-CM as follows:

Adverse Effect

When coding an adverse effect of a drug that has been correctly prescribed and properly administered, assign the appropriate code for the nature of the adverse effect followed by the appropriate code for the adverse effect of the drug (T36-T50). The code for the drug should have a 5th or 6th character “5” (for example T36.0X5-) Examples of the nature of an adverse effect are tachycardia, delirium, gastrointestinal hemorrhaging, vomiting, hypokalemia, hepatitis, renal failure, or respiratory failure.

Poisoning

When coding a poisoning or reaction to the improper use of a medication (e.g., overdose, wrong substance given or taken in error, wrong route of administration), first assign the appropriate code from categories T36-T50. The poisoning codes have an associated intent as their 5th or 6th character (accidental, intentional self-harm, assault and undetermined. If the intent of the poisoning is unknown or unspecified, code the intent as accidental intent. The undetermined intent is only for use if the documentation in the record specifies that the intent cannot be determined. Use additional code(s) for all manifestations of poisonings.

If there is also a diagnosis of abuse or dependence of the substance, the abuse or dependence is assigned as an additional code.

Examples of poisoning include:
  • Error was made in drug prescription
    Errors made in drug prescription or in the administration of the drug by provider, nurse, patient, or other person.
  • Overdose of a drug intentionally taken
    If an overdose of a drug was intentionally taken or administered and resulted in drug toxicity, it would be coded as a poisoning.
  • Nonprescribed drug taken with correctly prescribed and properly administered drug
    If a nonprescribed drug or medicinal agent was taken in combination with a correctly prescribed and properly administered drug, any drug toxicity or other reaction resulting from the interaction of the two drugs would be classified as a poisoning.
  • Interaction of drug(s) and alcohol
    When a reaction results from the interaction of a drug(s) and alcohol, this would be classified as poisoning.
Underdosing

Underdosing refers to taking less of a medication than is prescribed by a provider or a manufacturer's instruction. Discontinuing the use of a prescribed medication on the patient's own initiative (not directed by the patient's provider) is also classified as an underdosing. For underdosing, assign the code from categories T36-T50 (fifth or sixth character “6”).

Codes for underdosing should never be assigned as principal or first-listed codes. If a patient has a relapse or exacerbation of the medical condition for which the drug is prescribed because of the reduction in dose, then the medical condition itself should be coded.

Noncompliance (Z91.12-, Z91.13- and Z91.14-) or complication of care (Y63.6-Y63.9) codes are to be used with an underdosing code to indicate intent, if known.

Toxic Effects

When a harmful substance is ingested or comes in contact with a person, this is classified as a toxic effect. The toxic effect codes are in categories T51-T65.

Toxic effect codes have an associated intent: accidental, intentional self-harm, assault and undetermined.