• defects in the complement system
  • immunodeficiency disorders, except human immunodeficiency virus [HIV] disease
  • sarcoidosis


  • autoimmune disease (systemic) NOS (M35.9)
  • functional disorders of polymorphonuclear neutrophils (D71)
  • human immunodeficiency virus [HIV] disease (B20)
  1. D80 Immunodeficiency with predominantly antibody defects

    1. D80.0 Hereditary hypogammaglobulinemia

      Inclusion term(s):

      • Autosomal recessive agammaglobulinemia (Swiss type)
      • X-linked agammaglobulinemia [Bruton] (with growth hormone deficiency)
    2. D80.1 Nonfamilial hypogammaglobulinemia

      Inclusion term(s):

      • Agammaglobulinemia with immunoglobulin-bearing B-lymphocytes
      • Common variable agammaglobulinemia [CVAgamma]
      • Hypogammaglobulinemia NOS
    3. D80.2 Selective deficiency of immunoglobulin A [IgA]

    4. D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses

    5. D80.4 Selective deficiency of immunoglobulin M [IgM]

    6. D80.5 Immunodeficiency with increased immunoglobulin M [IgM]

    7. D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinemia

    8. D80.7 Transient hypogammaglobulinemia of infancy

    9. D80.8 Other immunodeficiencies with predominantly antibody defects

      Inclusion term(s):

      • Kappa light chain deficiency
    10. D80.9 Immunodeficiency with predominantly antibody defects, unspecified

Abbreviations used here:

NEC Not elsewhere classifiable
This abbreviation in the Tabular List represents “other specified”. When a specific code is not available for a condition, the Tabular List includes an NEC entry under a code to identify the code as the “other specified” code.

NOS Not otherwise specified
This abbreviation is the equivalent of unspecified.