The drug giving rise to the adverse effect should be identified by use of codes from categories T36-T50 with fifth or sixth character 5.

Use Additional code(s) to specify:
manifestations of poisoning
underdosing or failure in dosage during medical and surgical care (Y63.6, Y63.8-Y63.9)
underdosing of medication regimen (Z91.12-, Z91.13-)

Code first   , for adverse effects, the nature of the adverse effect, such as:
  adverse effect NOS (T88.7)
  aspirin gastritis (K29.-)
  blood disorders (D56-D76)
  contact dermatitis (L23-L25)
  dermatitis due to substances taken internally (L27.-)
  nephropathy (N14.0-N14.2)

Includes:

  • adverse effect of correct substance properly administered
  • poisoning by overdose of substance
  • poisoning by wrong substance given or taken in error
  • underdosing by (inadvertently) (deliberately) taking less substance than prescribed or instructed

Excludes1

  • toxic reaction to local anesthesia in pregnancy (O29.3-)

Excludes2

  • abuse and dependence of psychoactive substances (F10-F19)
  • abuse of non-dependence-producing substances (F55.-)
  • drug reaction and poisoning affecting newborn (P00-P96)
  • pathological drug intoxication (inebriation) (F10-F19)
  1. T43 Poisoning by, adverse effect of and underdosing of psychotropic drugs, not elsewhere classified

    Excludes1

    Excludes2

    • drug dependence and related mental and behavioral disorders due to psychoactive substance use (F10.- -F19.-)

    The appropriate 7th character is to be added to each code from category T43

    • A - initial encounter
    • D - subsequent encounter
    • S - sequela
    1. T43.0 Poisoning by, adverse effect of and underdosing of tricyclic and tetracyclic antidepressants

      1. T43.01 Poisoning by, adverse effect of and underdosing of tricyclic antidepressants

        • T43.011 Poisoning by tricyclic antidepressants, accidental (unintentional)

          Inclusion term(s):

          • Poisoning by tricyclic antidepressants NOS
        • T43.012 Poisoning by tricyclic antidepressants, intentional self-harm
        • T43.013 Poisoning by tricyclic antidepressants, assault
        • T43.014 Poisoning by tricyclic antidepressants, undetermined
        • T43.015 Adverse effect of tricyclic antidepressants
        • T43.016 Underdosing of tricyclic antidepressants
      2. T43.02 Poisoning by, adverse effect of and underdosing of tetracyclic antidepressants

        • T43.021 Poisoning by tetracyclic antidepressants, accidental (unintentional)

          Inclusion term(s):

          • Poisoning by tetracyclic antidepressants NOS
        • T43.022 Poisoning by tetracyclic antidepressants, intentional self-harm
        • T43.023 Poisoning by tetracyclic antidepressants, assault
        • T43.024 Poisoning by tetracyclic antidepressants, undetermined
        • T43.025 Adverse effect of tetracyclic antidepressants
        • T43.026 Underdosing of tetracyclic antidepressants
    2. T43.1 Poisoning by, adverse effect of and underdosing of monoamine-oxidase-inhibitor antidepressants

      1. T43.1X Poisoning by, adverse effect of and underdosing of monoamine-oxidase-inhibitor antidepressants

        • T43.1X1 Poisoning by monoamine-oxidase-inhibitor antidepressants, accidental (unintentional)

          Inclusion term(s):

          • Poisoning by monoamine-oxidase-inhibitor antidepressants NOS
        • T43.1X2 Poisoning by monoamine-oxidase-inhibitor antidepressants, intentional self-harm
        • T43.1X3 Poisoning by monoamine-oxidase-inhibitor antidepressants, assault
        • T43.1X4 Poisoning by monoamine-oxidase-inhibitor antidepressants, undetermined
        • T43.1X5 Adverse effect of monoamine-oxidase-inhibitor antidepressants
        • T43.1X6 Underdosing of monoamine-oxidase-inhibitor antidepressants
    3. T43.2 Poisoning by, adverse effect of and underdosing of other and unspecified antidepressants

      1. T43.20 Poisoning by, adverse effect of and underdosing of unspecified antidepressants

        • T43.201 Poisoning by unspecified antidepressants, accidental (unintentional)

          Inclusion term(s):

          • Poisoning by antidepressants NOS
        • T43.202 Poisoning by unspecified antidepressants, intentional self-harm
        • T43.203 Poisoning by unspecified antidepressants, assault
        • T43.204 Poisoning by unspecified antidepressants, undetermined
        • T43.205 Adverse effect of unspecified antidepressants

          Inclusion term(s):

          • Antidepressant discontinuation syndrome
        • T43.206 Underdosing of unspecified antidepressants
      2. T43.21 Poisoning by, adverse effect of and underdosing of selective serotonin and norepinephrine reuptake inhibitors

        Inclusion term(s):

        • Poisoning by, adverse effect of and underdosing of SSNRI antidepressants
        • T43.211 Poisoning by selective serotonin and norepinephrine reuptake inhibitors, accidental (unintentional)
        • T43.212 Poisoning by selective serotonin and norepinephrine reuptake inhibitors, intentional self-harm
        • T43.213 Poisoning by selective serotonin and norepinephrine reuptake inhibitors, assault
        • T43.214 Poisoning by selective serotonin and norepinephrine reuptake inhibitors, undetermined
        • T43.215 Adverse effect of selective serotonin and norepinephrine reuptake inhibitors
        • T43.216 Underdosing of selective serotonin and norepinephrine reuptake inhibitors
      3. T43.22 Poisoning by, adverse effect of and underdosing of selective serotonin reuptake inhibitors

        Inclusion term(s):

        • Poisoning by, adverse effect of and underdosing of SSRI antidepressants
        • T43.221 Poisoning by selective serotonin reuptake inhibitors, accidental (unintentional)
        • T43.222 Poisoning by selective serotonin reuptake inhibitors, intentional self-harm
        • T43.223 Poisoning by selective serotonin reuptake inhibitors, assault
        • T43.224 Poisoning by selective serotonin reuptake inhibitors, undetermined
        • T43.225 Adverse effect of selective serotonin reuptake inhibitors
        • T43.226 Underdosing of selective serotonin reuptake inhibitors
      4. T43.29 Poisoning by, adverse effect of and underdosing of other antidepressants

        • T43.291 Poisoning by other antidepressants, accidental (unintentional)

          Inclusion term(s):

          • Poisoning by other antidepressants NOS
        • T43.292 Poisoning by other antidepressants, intentional self-harm
        • T43.293 Poisoning by other antidepressants, assault
        • T43.294 Poisoning by other antidepressants, undetermined
        • T43.295 Adverse effect of other antidepressants
        • T43.296 Underdosing of other antidepressants
    4. T43.3 Poisoning by, adverse effect of and underdosing of phenothiazine antipsychotics and neuroleptics

      1. T43.3X Poisoning by, adverse effect of and underdosing of phenothiazine antipsychotics and neuroleptics

        • T43.3X1 Poisoning by phenothiazine antipsychotics and neuroleptics, accidental (unintentional)

          Inclusion term(s):

          • Poisoning by phenothiazine antipsychotics and neuroleptics NOS
        • T43.3X2 Poisoning by phenothiazine antipsychotics and neuroleptics, intentional self-harm
        • T43.3X3 Poisoning by phenothiazine antipsychotics and neuroleptics, assault
        • T43.3X4 Poisoning by phenothiazine antipsychotics and neuroleptics, undetermined
        • T43.3X5 Adverse effect of phenothiazine antipsychotics and neuroleptics
        • T43.3X6 Underdosing of phenothiazine antipsychotics and neuroleptics
    5. T43.4 Poisoning by, adverse effect of and underdosing of butyrophenone and thiothixene neuroleptics

      1. T43.4X Poisoning by, adverse effect of and underdosing of butyrophenone and thiothixene neuroleptics

        • T43.4X1 Poisoning by butyrophenone and thiothixene neuroleptics, accidental (unintentional)

          Inclusion term(s):

          • Poisoning by butyrophenone and thiothixene neuroleptics NOS
        • T43.4X2 Poisoning by butyrophenone and thiothixene neuroleptics, intentional self-harm
        • T43.4X3 Poisoning by butyrophenone and thiothixene neuroleptics, assault
        • T43.4X4 Poisoning by butyrophenone and thiothixene neuroleptics, undetermined
        • T43.4X5 Adverse effect of butyrophenone and thiothixene neuroleptics
        • T43.4X6 Underdosing of butyrophenone and thiothixene neuroleptics
    6. T43.5 Poisoning by, adverse effect of and underdosing of other and unspecified antipsychotics and neuroleptics

      1. T43.50 Poisoning by, adverse effect of and underdosing of unspecified antipsychotics and neuroleptics

        • T43.501 Poisoning by unspecified antipsychotics and neuroleptics, accidental (unintentional)

          Inclusion term(s):

          • Poisoning by antipsychotics and neuroleptics NOS
        • T43.502 Poisoning by unspecified antipsychotics and neuroleptics, intentional self-harm
        • T43.503 Poisoning by unspecified antipsychotics and neuroleptics, assault
        • T43.504 Poisoning by unspecified antipsychotics and neuroleptics, undetermined
        • T43.505 Adverse effect of unspecified antipsychotics and neuroleptics
        • T43.506 Underdosing of unspecified antipsychotics and neuroleptics
      2. T43.59 Poisoning by, adverse effect of and underdosing of other antipsychotics and neuroleptics

        • T43.591 Poisoning by other antipsychotics and neuroleptics, accidental (unintentional)

          Inclusion term(s):

          • Poisoning by other antipsychotics and neuroleptics NOS
        • T43.592 Poisoning by other antipsychotics and neuroleptics, intentional self-harm
        • T43.593 Poisoning by other antipsychotics and neuroleptics, assault
        • T43.594 Poisoning by other antipsychotics and neuroleptics, undetermined
        • T43.595 Adverse effect of other antipsychotics and neuroleptics
        • T43.596 Underdosing of other antipsychotics and neuroleptics
    7. T43.6 Poisoning by, adverse effect of and underdosing of psychostimulants

      1. T43.60 Poisoning by, adverse effect of and underdosing of unspecified psychostimulant

        • T43.601 Poisoning by unspecified psychostimulants, accidental (unintentional)

          Inclusion term(s):

          • Poisoning by psychostimulants NOS
        • T43.602 Poisoning by unspecified psychostimulants, intentional self-harm
        • T43.603 Poisoning by unspecified psychostimulants, assault
        • T43.604 Poisoning by unspecified psychostimulants, undetermined
        • T43.605 Adverse effect of unspecified psychostimulants
        • T43.606 Underdosing of unspecified psychostimulants
      2. T43.61 Poisoning by, adverse effect of and underdosing of caffeine

        • T43.611 Poisoning by caffeine, accidental (unintentional)

          Inclusion term(s):

          • Poisoning by caffeine NOS
        • T43.612 Poisoning by caffeine, intentional self-harm
        • T43.613 Poisoning by caffeine, assault
        • T43.614 Poisoning by caffeine, undetermined
        • T43.615 Adverse effect of caffeine
        • T43.616 Underdosing of caffeine
      3. T43.62 Poisoning by, adverse effect of and underdosing of amphetamines

        Inclusion term(s):

        • Poisoning by, adverse effect of and underdosing of methamphetamines
        • T43.621 Poisoning by amphetamines, accidental (unintentional)

          Inclusion term(s):

          • Poisoning by amphetamines NOS
        • T43.622 Poisoning by amphetamines, intentional self-harm
        • T43.623 Poisoning by amphetamines, assault
        • T43.624 Poisoning by amphetamines, undetermined
        • T43.625 Adverse effect of amphetamines
        • T43.626 Underdosing of amphetamines
      4. T43.63 Poisoning by, adverse effect of and underdosing of methylphenidate

        • T43.631 Poisoning by methylphenidate, accidental (unintentional)

          Inclusion term(s):

          • Poisoning by methylphenidate NOS
        • T43.632 Poisoning by methylphenidate, intentional self-harm
        • T43.633 Poisoning by methylphenidate, assault
        • T43.634 Poisoning by methylphenidate, undetermined
        • T43.635 Adverse effect of methylphenidate
        • T43.636 Underdosing of methylphenidate
      5. T43.64 Poisoning by ecstasy

        Inclusion term(s):

        • Poisoning by MDMA
        • Poisoning by 3,4-methylenedioxymethamphetamine
        • T43.641 Poisoning by ecstasy, accidental (unintentional)

          Inclusion term(s):

          • Poisoning by ecstasy NOS
        • T43.642 Poisoning by ecstasy, intentional self-harm
        • T43.643 Poisoning by ecstasy, assault
        • T43.644 Poisoning by ecstasy, undetermined
      6. T43.69 Poisoning by, adverse effect of and underdosing of other psychostimulants

        • T43.691 Poisoning by other psychostimulants, accidental (unintentional)

          Inclusion term(s):

          • Poisoning by other psychostimulants NOS
        • T43.692 Poisoning by other psychostimulants, intentional self-harm
        • T43.693 Poisoning by other psychostimulants, assault
        • T43.694 Poisoning by other psychostimulants, undetermined
        • T43.695 Adverse effect of other psychostimulants
        • T43.696 Underdosing of other psychostimulants
    8. T43.8 Poisoning by, adverse effect of and underdosing of other psychotropic drugs

      1. T43.8X Poisoning by, adverse effect of and underdosing of other psychotropic drugs

        • T43.8X1 Poisoning by other psychotropic drugs, accidental (unintentional)

          Inclusion term(s):

          • Poisoning by other psychotropic drugs NOS
        • T43.8X2 Poisoning by other psychotropic drugs, intentional self-harm
        • T43.8X3 Poisoning by other psychotropic drugs, assault
        • T43.8X4 Poisoning by other psychotropic drugs, undetermined
        • T43.8X5 Adverse effect of other psychotropic drugs
        • T43.8X6 Underdosing of other psychotropic drugs
    9. T43.9 Poisoning by, adverse effect of and underdosing of unspecified psychotropic drug

      1. T43.91 Poisoning by unspecified psychotropic drug, accidental (unintentional)

        Inclusion term(s):

        • Poisoning by psychotropic drug NOS
      2. T43.92 Poisoning by unspecified psychotropic drug, intentional self-harm

      3. T43.93 Poisoning by unspecified psychotropic drug, assault

      4. T43.94 Poisoning by unspecified psychotropic drug, undetermined

      5. T43.95 Adverse effect of unspecified psychotropic drug

      6. T43.96 Underdosing of unspecified psychotropic drug

Abbreviations used here:

NEC Not elsewhere classifiable
This abbreviation in the Tabular List represents “other specified”. When a specific code is not available for a condition, the Tabular List includes an NEC entry under a code to identify the code as the “other specified” code.

NOS Not otherwise specified
This abbreviation is the equivalent of unspecified.