The drug giving rise to the adverse effect should be identified by use of codes from categories T36-T50 with fifth or sixth character 5.

Use Additional code(s) to specify:
manifestations of poisoning
underdosing or failure in dosage during medical and surgical care (Y63.6, Y63.8-Y63.9)
underdosing of medication regimen (Z91.12-, Z91.13-)

Code first   , for adverse effects, the nature of the adverse effect, such as:
  adverse effect NOS (T88.7)
  aspirin gastritis (K29.-)
  blood disorders (D56-D76)
  contact dermatitis (L23-L25)
  dermatitis due to substances taken internally (L27.-)
  nephropathy (N14.0-N14.2)

Includes:

  • adverse effect of correct substance properly administered
  • poisoning by overdose of substance
  • poisoning by wrong substance given or taken in error
  • underdosing by (inadvertently) (deliberately) taking less substance than prescribed or instructed

Excludes1

  • toxic reaction to local anesthesia in pregnancy (O29.3-)

Excludes2

  • abuse and dependence of psychoactive substances (F10-F19)
  • abuse of non-dependence-producing substances (F55.-)
  • drug reaction and poisoning affecting newborn (P00-P96)
  • pathological drug intoxication (inebriation) (F10-F19)
  1. T48 Poisoning by, adverse effect of and underdosing of agents primarily acting on smooth and skeletal muscles and the respiratory system

    The appropriate 7th character is to be added to each code from category T48

    • A - initial encounter
    • D - subsequent encounter
    • S - sequela
    1. T48.0 Poisoning by, adverse effect of and underdosing of oxytocic drugs

      1. T48.0X Poisoning by, adverse effect of and underdosing of oxytocic drugs

        • T48.0X1 Poisoning by oxytocic drugs, accidental (unintentional)

          Inclusion term(s):

          • Poisoning by oxytocic drugs NOS
        • T48.0X2 Poisoning by oxytocic drugs, intentional self-harm
        • T48.0X3 Poisoning by oxytocic drugs, assault
        • T48.0X4 Poisoning by oxytocic drugs, undetermined
        • T48.0X5 Adverse effect of oxytocic drugs
        • T48.0X6 Underdosing of oxytocic drugs
    2. T48.1 Poisoning by, adverse effect of and underdosing of skeletal muscle relaxants [neuromuscular blocking agents]

      1. T48.1X Poisoning by, adverse effect of and underdosing of skeletal muscle relaxants [neuromuscular blocking agents]

        • T48.1X1 Poisoning by skeletal muscle relaxants [neuromuscular blocking agents], accidental (unintentional)

          Inclusion term(s):

          • Poisoning by skeletal muscle relaxants [neuromuscular blocking agents] NOS
        • T48.1X2 Poisoning by skeletal muscle relaxants [neuromuscular blocking agents], intentional self-harm
        • T48.1X3 Poisoning by skeletal muscle relaxants [neuromuscular blocking agents], assault
        • T48.1X4 Poisoning by skeletal muscle relaxants [neuromuscular blocking agents], undetermined
        • T48.1X5 Adverse effect of skeletal muscle relaxants [neuromuscular blocking agents]
        • T48.1X6 Underdosing of skeletal muscle relaxants [neuromuscular blocking agents]
    3. T48.2 Poisoning by, adverse effect of and underdosing of other and unspecified drugs acting on muscles

      1. T48.20 Poisoning by, adverse effect of and underdosing of unspecified drugs acting on muscles

        • T48.201 Poisoning by unspecified drugs acting on muscles, accidental (unintentional)

          Inclusion term(s):

          • Poisoning by unspecified drugs acting on muscles NOS
        • T48.202 Poisoning by unspecified drugs acting on muscles, intentional self-harm
        • T48.203 Poisoning by unspecified drugs acting on muscles, assault
        • T48.204 Poisoning by unspecified drugs acting on muscles, undetermined
        • T48.205 Adverse effect of unspecified drugs acting on muscles
        • T48.206 Underdosing of unspecified drugs acting on muscles
      2. T48.29 Poisoning by, adverse effect of and underdosing of other drugs acting on muscles

        • T48.291 Poisoning by other drugs acting on muscles, accidental (unintentional)

          Inclusion term(s):

          • Poisoning by other drugs acting on muscles NOS
        • T48.292 Poisoning by other drugs acting on muscles, intentional self-harm
        • T48.293 Poisoning by other drugs acting on muscles, assault
        • T48.294 Poisoning by other drugs acting on muscles, undetermined
        • T48.295 Adverse effect of other drugs acting on muscles
        • T48.296 Underdosing of other drugs acting on muscles
    4. T48.3 Poisoning by, adverse effect of and underdosing of antitussives

      1. T48.3X Poisoning by, adverse effect of and underdosing of antitussives

        • T48.3X1 Poisoning by antitussives, accidental (unintentional)

          Inclusion term(s):

          • Poisoning by antitussives NOS
        • T48.3X2 Poisoning by antitussives, intentional self-harm
        • T48.3X3 Poisoning by antitussives, assault
        • T48.3X4 Poisoning by antitussives, undetermined
        • T48.3X5 Adverse effect of antitussives
        • T48.3X6 Underdosing of antitussives
    5. T48.4 Poisoning by, adverse effect of and underdosing of expectorants

      1. T48.4X Poisoning by, adverse effect of and underdosing of expectorants

        • T48.4X1 Poisoning by expectorants, accidental (unintentional)

          Inclusion term(s):

          • Poisoning by expectorants NOS
        • T48.4X2 Poisoning by expectorants, intentional self-harm
        • T48.4X3 Poisoning by expectorants, assault
        • T48.4X4 Poisoning by expectorants, undetermined
        • T48.4X5 Adverse effect of expectorants
        • T48.4X6 Underdosing of expectorants
    6. T48.5 Poisoning by, adverse effect of and underdosing of other anti-common-cold drugs

      Inclusion term(s):

      • Poisoning by, adverse effect of and underdosing of decongestants
      1. T48.5X Poisoning by, adverse effect of and underdosing of other anti-common-cold drugs

        • T48.5X1 Poisoning by other anti-common-cold drugs, accidental (unintentional)

          Inclusion term(s):

          • Poisoning by other anti-common-cold drugs NOS
        • T48.5X2 Poisoning by other anti-common-cold drugs, intentional self-harm
        • T48.5X3 Poisoning by other anti-common-cold drugs, assault
        • T48.5X4 Poisoning by other anti-common-cold drugs, undetermined
        • T48.5X5 Adverse effect of other anti-common-cold drugs
        • T48.5X6 Underdosing of other anti-common-cold drugs
    7. T48.6 Poisoning by, adverse effect of and underdosing of antiasthmatics, not elsewhere classified

      Inclusion term(s):

      • Poisoning by, adverse effect of and underdosing of beta-adrenoreceptor agonists used in asthma therapy
      1. T48.6X Poisoning by, adverse effect of and underdosing of antiasthmatics

        • T48.6X1 Poisoning by antiasthmatics, accidental (unintentional)

          Inclusion term(s):

          • Poisoning by antiasthmatics NOS
        • T48.6X2 Poisoning by antiasthmatics, intentional self-harm
        • T48.6X3 Poisoning by antiasthmatics, assault
        • T48.6X4 Poisoning by antiasthmatics, undetermined
        • T48.6X5 Adverse effect of antiasthmatics
        • T48.6X6 Underdosing of antiasthmatics
    8. T48.9 Poisoning by, adverse effect of and underdosing of other and unspecified agents primarily acting on the respiratory system

      1. T48.90 Poisoning by, adverse effect of and underdosing of unspecified agents primarily acting on the respiratory system

        • T48.901 Poisoning by unspecified agents primarily acting on the respiratory system, accidental (unintentional)
        • T48.902 Poisoning by unspecified agents primarily acting on the respiratory system, intentional self-harm
        • T48.903 Poisoning by unspecified agents primarily acting on the respiratory system, assault
        • T48.904 Poisoning by unspecified agents primarily acting on the respiratory system, undetermined
        • T48.905 Adverse effect of unspecified agents primarily acting on the respiratory system
        • T48.906 Underdosing of unspecified agents primarily acting on the respiratory system
      2. T48.99 Poisoning by, adverse effect of and underdosing of other agents primarily acting on the respiratory system

        • T48.991 Poisoning by other agents primarily acting on the respiratory system, accidental (unintentional)
        • T48.992 Poisoning by other agents primarily acting on the respiratory system, intentional self-harm
        • T48.993 Poisoning by other agents primarily acting on the respiratory system, assault
        • T48.994 Poisoning by other agents primarily acting on the respiratory system, undetermined
        • T48.995 Adverse effect of other agents primarily acting on the respiratory system
        • T48.996 Underdosing of other agents primarily acting on the respiratory system
Abbreviations used here:

NEC Not elsewhere classifiable
This abbreviation in the Tabular List represents “other specified”. When a specific code is not available for a condition, the Tabular List includes an NEC entry under a code to identify the code as the “other specified” code.

NOS Not otherwise specified
This abbreviation is the equivalent of unspecified.