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Substance Poisoning
Accidental (unintentional)
Intentional (self-harm)
Adhesive NEC T65.891 T65.892 T65.893 T65.894 -- --
Adicillin T36.0X1 T36.0X2 T36.0X3 T36.0X4 T36.0X5 T36.0X6
Adiphenine T44.3X1 T44.3X2 T44.3X3 T44.3X4 T44.3X5 T44.3X6
Adipiodone T50.8X1 T50.8X2 T50.8X3 T50.8X4 T50.8X5 T50.8X6
Adjunct, pharmaceutical T50.901 T50.902 T50.903 T50.904 T50.905 T50.906
Adrenal (extract, cortex or medulla)(glucocorticoids)(hormones)(mineralocorticoids) T38.0X1 T38.0X2 T38.0X3 T38.0X4 T38.0X5 T38.0X6
– ENT agent T49.6X1 T49.6X2 T49.6X3 T49.6X4 T49.6X5 T49.6X6
– ophthalmic preparation T49.5X1 T49.5X2 T49.5X3 T49.5X4 T49.5X5 T49.5X6
– topical NEC T49.0X1 T49.0X2 T49.0X3 T49.0X4 T49.0X5 T49.0X6
Adrenaline T44.5X1 T44.5X2 T44.5X3 T44.5X4 T44.5X5 T44.5X6
Adrenergic NEC T44.901 T44.902 T44.903 T44.904 T44.905 T44.906
– blocking agent NEC T44.8X1 T44.8X2 T44.8X3 T44.8X4 T44.8X5 T44.8X6
– – beta, heart T44.7X1 T44.7X2 T44.7X3 T44.7X4 T44.7X5 T44.7X6
– specified NEC T44.991 T44.992 T44.993 T44.994 T44.995 T44.996
– semicarbazone (mono) T46.991 T46.992 T46.993 T46.994 T46.995 T46.996
– derivative T46.991 T46.992 T46.993 T46.994 T46.995 T46.996
Adrenocorticotrophic hormone T38.811 T38.812 T38.813 T38.814 T38.815 T38.816

The occurrence of drug toxicity is classified in ICD-10-CM as follows:

Adverse Effect

When coding an adverse effect of a drug that has been correctly prescribed and properly administered, assign the appropriate code for the nature of the adverse effect followed by the appropriate code for the adverse effect of the drug (T36-T50). The code for the drug should have a 5th or 6th character “5” (for example T36.0X5-) Examples of the nature of an adverse effect are tachycardia, delirium, gastrointestinal hemorrhaging, vomiting, hypokalemia, hepatitis, renal failure, or respiratory failure.


When coding a poisoning or reaction to the improper use of a medication (e.g., overdose, wrong substance given or taken in error, wrong route of administration), first assign the appropriate code from categories T36-T50. The poisoning codes have an associated intent as their 5th or 6th character (accidental, intentional self-harm, assault and undetermined. If the intent of the poisoning is unknown or unspecified, code the intent as accidental intent. The undetermined intent is only for use if the documentation in the record specifies that the intent cannot be determined. Use additional code(s) for all manifestations of poisonings.

If there is also a diagnosis of abuse or dependence of the substance, the abuse or dependence is assigned as an additional code.

Examples of poisoning include:
  • Error was made in drug prescription
    Errors made in drug prescription or in the administration of the drug by provider, nurse, patient, or other person.
  • Overdose of a drug intentionally taken
    If an overdose of a drug was intentionally taken or administered and resulted in drug toxicity, it would be coded as a poisoning.
  • Nonprescribed drug taken with correctly prescribed and properly administered drug
    If a nonprescribed drug or medicinal agent was taken in combination with a correctly prescribed and properly administered drug, any drug toxicity or other reaction resulting from the interaction of the two drugs would be classified as a poisoning.
  • Interaction of drug(s) and alcohol
    When a reaction results from the interaction of a drug(s) and alcohol, this would be classified as poisoning.

Underdosing refers to taking less of a medication than is prescribed by a provider or a manufacturer's instruction. Discontinuing the use of a prescribed medication on the patient's own initiative (not directed by the patient's provider) is also classified as an underdosing. For underdosing, assign the code from categories T36-T50 (fifth or sixth character “6”).

Codes for underdosing should never be assigned as principal or first-listed codes. If a patient has a relapse or exacerbation of the medical condition for which the drug is prescribed because of the reduction in dose, then the medical condition itself should be coded.

Noncompliance (Z91.12-, Z91.13- and Z91.14-) or complication of care (Y63.6-Y63.9) codes are to be used with an underdosing code to indicate intent, if known.

Toxic Effects

When a harmful substance is ingested or comes in contact with a person, this is classified as a toxic effect. The toxic effect codes are in categories T51-T65.

Toxic effect codes have an associated intent: accidental, intentional self-harm, assault and undetermined.