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Substance Poisoning
Accidental (unintentional)
Intentional (self-harm)
Acetyldigitoxin T46.0X1 T46.0X2 T46.0X3 T46.0X4 T46.0X5 T46.0X6
Acetyldigoxin T46.0X1 T46.0X2 T46.0X3 T46.0X4 T46.0X5 T46.0X6
Acetyldihydrocodeine T40.2X1 T40.2X2 T40.2X3 T40.2X4 -- --
Acetyldihydrocodeinone T40.2X1 T40.2X2 T40.2X3 T40.2X4 -- --
Acetylene (gas) T59.891 T59.892 T59.893 T59.894 -- --
– dichloride T53.6X1 T53.6X2 T53.6X3 T53.6X4 -- --
– incomplete combustion of T58.11 T58.12 T58.13 T58.14 -- --
– industrial T59.891 T59.892 T59.893 T59.894 -- --
– tetrachloride T53.6X1 T53.6X2 T53.6X3 T53.6X4 -- --
– – vapor T53.6X1 T53.6X2 T53.6X3 T53.6X4 -- --
Acetylpheneturide T42.6X1 T42.6X2 T42.6X3 T42.6X4 T42.6X5 T42.6X6
Acetylphenylhydrazine T39.8X1 T39.8X2 T39.8X3 T39.8X4 T39.8X5 T39.8X6
Acetylsalicylic acid (salts) T39.011 T39.012 T39.013 T39.014 T39.015 T39.016
– enteric coated T39.011 T39.012 T39.013 T39.014 T39.015 T39.016
Acetylsulfamethoxypyridazine T37.0X1 T37.0X2 T37.0X3 T37.0X4 T37.0X5 T37.0X6
Achromycin T36.4X1 T36.4X2 T36.4X3 T36.4X4 T36.4X5 T36.4X6
– ophthalmic preparation T49.5X1 T49.5X2 T49.5X3 T49.5X4 T49.5X5 T49.5X6
– topical NEC T49.0X1 T49.0X2 T49.0X3 T49.0X4 T49.0X5 T49.0X6

The occurrence of drug toxicity is classified in ICD-10-CM as follows:

Adverse Effect

When coding an adverse effect of a drug that has been correctly prescribed and properly administered, assign the appropriate code for the nature of the adverse effect followed by the appropriate code for the adverse effect of the drug (T36-T50). The code for the drug should have a 5th or 6th character “5” (for example T36.0X5-) Examples of the nature of an adverse effect are tachycardia, delirium, gastrointestinal hemorrhaging, vomiting, hypokalemia, hepatitis, renal failure, or respiratory failure.


When coding a poisoning or reaction to the improper use of a medication (e.g., overdose, wrong substance given or taken in error, wrong route of administration), first assign the appropriate code from categories T36-T50. The poisoning codes have an associated intent as their 5th or 6th character (accidental, intentional self-harm, assault and undetermined. If the intent of the poisoning is unknown or unspecified, code the intent as accidental intent. The undetermined intent is only for use if the documentation in the record specifies that the intent cannot be determined. Use additional code(s) for all manifestations of poisonings.

If there is also a diagnosis of abuse or dependence of the substance, the abuse or dependence is assigned as an additional code.

Examples of poisoning include:
  • Error was made in drug prescription
    Errors made in drug prescription or in the administration of the drug by provider, nurse, patient, or other person.
  • Overdose of a drug intentionally taken
    If an overdose of a drug was intentionally taken or administered and resulted in drug toxicity, it would be coded as a poisoning.
  • Nonprescribed drug taken with correctly prescribed and properly administered drug
    If a nonprescribed drug or medicinal agent was taken in combination with a correctly prescribed and properly administered drug, any drug toxicity or other reaction resulting from the interaction of the two drugs would be classified as a poisoning.
  • Interaction of drug(s) and alcohol
    When a reaction results from the interaction of a drug(s) and alcohol, this would be classified as poisoning.

Underdosing refers to taking less of a medication than is prescribed by a provider or a manufacturer's instruction. Discontinuing the use of a prescribed medication on the patient's own initiative (not directed by the patient's provider) is also classified as an underdosing. For underdosing, assign the code from categories T36-T50 (fifth or sixth character “6”).

Codes for underdosing should never be assigned as principal or first-listed codes. If a patient has a relapse or exacerbation of the medical condition for which the drug is prescribed because of the reduction in dose, then the medical condition itself should be coded.

Noncompliance (Z91.12-, Z91.13- and Z91.14-) or complication of care (Y63.6-Y63.9) codes are to be used with an underdosing code to indicate intent, if known.

Toxic Effects

When a harmful substance is ingested or comes in contact with a person, this is classified as a toxic effect. The toxic effect codes are in categories T51-T65.

Toxic effect codes have an associated intent: accidental, intentional self-harm, assault and undetermined.