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ICD 10 Code T50.8X5A

Adverse effect of diagnostic agents, initial encounter

T50.8X5A is a valid billable ICD-10 diagnosis code for Adverse effect of diagnostic agents, initial encounter. It is found in the 2025 version of the ICD-10 Clinical Modification (CM) and can be used in all HIPAA-covered transactions from Oct 01, 2024 - Sep 30, 2025.

↓ See below for any exclusions, inclusions or special notations

When using code T50.8X5A in processing claims, check the following: — See additional coding rules

  • Adult diagnoses - Age range is 15–124 years inclusive (e.g., senile delirium, mature cataract).

More specific codes
7th Character selection:

See also, ICD-10 Table of Drugs & Chemicals.

MS-DRG - Medicare Severity-Diagnosis Related Group
  • MDC 15 Newborns & Other Neonates with Conditions Originating in Perinatal Period
    Prematurity
    • DRG 791 - PREMATURITY WITH MAJOR PROBLEMS
  • MDC 15 Newborns & Other Neonates with Conditions Originating in Perinatal Period
    Full Term Neonate with Major Problems
    • DRG 793 - FULL TERM NEONATE WITH MAJOR PROBLEMS
  • MDC 21 Injuries, Poisonings & Toxic Effects of Drugs
    Poisoning and Toxic Effects of Drugs
    • DRG 917 - POISONING AND TOXIC EFFECTS OF DRUGS WITH MCC
    • DRG 918 - POISONING AND TOXIC EFFECTS OF DRUGS WITHOUT MCC
Coding structure:

ICD-10 code T50.8X5A is based on the following Tabular structure:

Chapter 19: Injury, poisoning and certain other consequences of external causes
  • Section T36-T50: Poisoning by, adverse effects of and underdosing of drugs, medicaments and biological substances
    • Category T50: Poisoning by, adverse effect of and underdosing of diuretics and other and unspecified drugs, medicaments and biological substances

↑ Parent code:
T50.8X5 for Adverse effect of diagnostic agents

Should you use T50.8X5A or T508X5A (with or without decimal point)?
DO NOT include the decimal point when electronically filing claims as it may be rejected. Some clearinghouses may remove it for you but to avoid having a rejected claim due to an invalid ICD-10 code, do not include the decimal point when submitting claims electronically.

Section T36-T50 — Poisoning by, adverse effects of and underdosing of drugs, medicaments and biological substances

The drug giving rise to the adverse effect should be identified by use of codes from categories T36-T50 with fifth or sixth character 5.

Use additional code(s) to specify:
manifestations of poisoning
underdosing or failure in dosage during medical and surgical care (Y63.6, Y63.8-Y63.9)
underdosing of medication regimen (Z91.12-, Z91.13-)

Code first  , for adverse effects, the nature of the adverse effect, such as:
  adverse effect NOS (T88.7)
  aspirin gastritis (K29.-)
  blood disorders (D56-D76)
  contact dermatitis (L23-L25)
  dermatitis due to substances taken internally (L27.-)
  nephropathy (N14.0-N14.2)

Includes:

  • adverse effect of correct substance properly administered
  • poisoning by overdose of substance
  • poisoning by wrong substance given or taken in error
  • underdosing by (inadvertently) (deliberately) taking less substance than prescribed or instructed

Excludes1

  • toxic reaction to local anesthesia in pregnancy (O29.3-)

Excludes2

  • abuse and dependence of psychoactive substances (F10-F19)
  • abuse of non-dependence-producing substances (F55.-)
  • immunodeficiency due to drugs (D84.821)
  • drug reaction and poisoning affecting newborn (P00-P96)
  • pathological drug intoxication (inebriation) (F10-F19)

  1. T50 Poisoning by, adverse effect of and underdosing of diuretics and other and unspecified drugs, medicaments and biological substances

    The appropriate 7th character is to be added to each code from category T50

    • A - initial encounter
    • D - subsequent encounter
    • S - sequela

    1. T50.0 Poisoning by, adverse effect of and underdosing of mineralocorticoids and their antagonists

      1. T50.0X Poisoning by, adverse effect of and underdosing of mineralocorticoids and their antagonists

        • T50.0X1 Poisoning by mineralocorticoids and their antagonists, accidental (unintentional)

          Inclusion term(s):

          • Poisoning by mineralocorticoids and their antagonists NOS
        • T50.0X2 Poisoning by mineralocorticoids and their antagonists, intentional self-harm
        • T50.0X3 Poisoning by mineralocorticoids and their antagonists, assault
        • T50.0X4 Poisoning by mineralocorticoids and their antagonists, undetermined
        • T50.0X5 Adverse effect of mineralocorticoids and their antagonists
        • T50.0X6 Underdosing of mineralocorticoids and their antagonists

    2. T50.1 Poisoning by, adverse effect of and underdosing of loop [high-ceiling] diuretics

      1. T50.1X Poisoning by, adverse effect of and underdosing of loop [high-ceiling] diuretics

        • T50.1X1 Poisoning by loop [high-ceiling] diuretics, accidental (unintentional)

          Inclusion term(s):

          • Poisoning by loop [high-ceiling] diuretics NOS
        • T50.1X2 Poisoning by loop [high-ceiling] diuretics, intentional self-harm
        • T50.1X3 Poisoning by loop [high-ceiling] diuretics, assault
        • T50.1X4 Poisoning by loop [high-ceiling] diuretics, undetermined
        • T50.1X5 Adverse effect of loop [high-ceiling] diuretics
        • T50.1X6 Underdosing of loop [high-ceiling] diuretics

    3. T50.2 Poisoning by, adverse effect of and underdosing of carbonic-anhydrase inhibitors, benzothiadiazides and other diuretics

      Inclusion term(s):

      • Poisoning by, adverse effect of and underdosing of acetazolamide

      1. T50.2X Poisoning by, adverse effect of and underdosing of carbonic-anhydrase inhibitors, benzothiadiazides and other diuretics

        • T50.2X1 Poisoning by carbonic-anhydrase inhibitors, benzothiadiazides and other diuretics, accidental (unintentional)

          Inclusion term(s):

          • Poisoning by carbonic-anhydrase inhibitors, benzothiadiazides and other diuretics NOS
        • T50.2X2 Poisoning by carbonic-anhydrase inhibitors, benzothiadiazides and other diuretics, intentional self-harm
        • T50.2X3 Poisoning by carbonic-anhydrase inhibitors, benzothiadiazides and other diuretics, assault
        • T50.2X4 Poisoning by carbonic-anhydrase inhibitors, benzothiadiazides and other diuretics, undetermined
        • T50.2X5 Adverse effect of carbonic-anhydrase inhibitors, benzothiadiazides and other diuretics
        • T50.2X6 Underdosing of carbonic-anhydrase inhibitors, benzothiadiazides and other diuretics

    4. T50.3 Poisoning by, adverse effect of and underdosing of electrolytic, caloric and water-balance agents

      Inclusion term(s):

      • Poisoning by, adverse effect of and underdosing of oral rehydration salts

      1. T50.3X Poisoning by, adverse effect of and underdosing of electrolytic, caloric and water-balance agents

        • T50.3X1 Poisoning by electrolytic, caloric and water-balance agents, accidental (unintentional)

          Inclusion term(s):

          • Poisoning by electrolytic, caloric and water-balance agents NOS
        • T50.3X2 Poisoning by electrolytic, caloric and water-balance agents, intentional self-harm
        • T50.3X3 Poisoning by electrolytic, caloric and water-balance agents, assault
        • T50.3X4 Poisoning by electrolytic, caloric and water-balance agents, undetermined
        • T50.3X5 Adverse effect of electrolytic, caloric and water-balance agents
        • T50.3X6 Underdosing of electrolytic, caloric and water-balance agents

    5. T50.4 Poisoning by, adverse effect of and underdosing of drugs affecting uric acid metabolism

      1. T50.4X Poisoning by, adverse effect of and underdosing of drugs affecting uric acid metabolism

        • T50.4X1 Poisoning by drugs affecting uric acid metabolism, accidental (unintentional)

          Inclusion term(s):

          • Poisoning by drugs affecting uric acid metabolism NOS
        • T50.4X2 Poisoning by drugs affecting uric acid metabolism, intentional self-harm
        • T50.4X3 Poisoning by drugs affecting uric acid metabolism, assault
        • T50.4X4 Poisoning by drugs affecting uric acid metabolism, undetermined
        • T50.4X5 Adverse effect of drugs affecting uric acid metabolism
        • T50.4X6 Underdosing of drugs affecting uric acid metabolism

    6. T50.5 Poisoning by, adverse effect of and underdosing of appetite depressants

      1. T50.5X Poisoning by, adverse effect of and underdosing of appetite depressants

        • T50.5X1 Poisoning by appetite depressants, accidental (unintentional)

          Inclusion term(s):

          • Poisoning by appetite depressants NOS
        • T50.5X2 Poisoning by appetite depressants, intentional self-harm
        • T50.5X3 Poisoning by appetite depressants, assault
        • T50.5X4 Poisoning by appetite depressants, undetermined
        • T50.5X5 Adverse effect of appetite depressants
        • T50.5X6 Underdosing of appetite depressants

    7. T50.6 Poisoning by, adverse effect of and underdosing of antidotes and chelating agents

      Inclusion term(s):

      • Poisoning by, adverse effect of and underdosing of alcohol deterrents

      1. T50.6X Poisoning by, adverse effect of and underdosing of antidotes and chelating agents

        • T50.6X1 Poisoning by antidotes and chelating agents, accidental (unintentional)

          Inclusion term(s):

          • Poisoning by antidotes and chelating agents NOS
        • T50.6X2 Poisoning by antidotes and chelating agents, intentional self-harm
        • T50.6X3 Poisoning by antidotes and chelating agents, assault
        • T50.6X4 Poisoning by antidotes and chelating agents, undetermined
        • T50.6X5 Adverse effect of antidotes and chelating agents
        • T50.6X6 Underdosing of antidotes and chelating agents

    8. T50.7 Poisoning by, adverse effect of and underdosing of analeptics and opioid receptor antagonists

      1. T50.7X Poisoning by, adverse effect of and underdosing of analeptics and opioid receptor antagonists

        • T50.7X1 Poisoning by analeptics and opioid receptor antagonists, accidental (unintentional)

          Inclusion term(s):

          • Poisoning by analeptics and opioid receptor antagonists NOS
        • T50.7X2 Poisoning by analeptics and opioid receptor antagonists, intentional self-harm
        • T50.7X3 Poisoning by analeptics and opioid receptor antagonists, assault
        • T50.7X4 Poisoning by analeptics and opioid receptor antagonists, undetermined
        • T50.7X5 Adverse effect of analeptics and opioid receptor antagonists
        • T50.7X6 Underdosing of analeptics and opioid receptor antagonists

    9. T50.8 Poisoning by, adverse effect of and underdosing of diagnostic agents

      1. T50.8X Poisoning by, adverse effect of and underdosing of diagnostic agents

        • T50.8X1 Poisoning by diagnostic agents, accidental (unintentional)

          Inclusion term(s):

          • Poisoning by diagnostic agents NOS
        • T50.8X2 Poisoning by diagnostic agents, intentional self-harm
        • T50.8X3 Poisoning by diagnostic agents, assault
        • T50.8X4 Poisoning by diagnostic agents, undetermined
        • T50.8X5 Adverse effect of diagnostic agents
        • T50.8X6 Underdosing of diagnostic agents

    10. T50.9 Poisoning by, adverse effect of and underdosing of other and unspecified drugs, medicaments and biological substances

      1. T50.90 Poisoning by, adverse effect of and underdosing of unspecified drugs, medicaments and biological substances

        • T50.901 Poisoning by unspecified drugs, medicaments and biological substances, accidental (unintentional)
        • T50.902 Poisoning by unspecified drugs, medicaments and biological substances, intentional self-harm
        • T50.903 Poisoning by unspecified drugs, medicaments and biological substances, assault
        • T50.904 Poisoning by unspecified drugs, medicaments and biological substances, undetermined
        • T50.905 Adverse effect of unspecified drugs, medicaments and biological substances
        • T50.906 Underdosing of unspecified drugs, medicaments and biological substances

      2. T50.91 Poisoning by, adverse effect of and underdosing of multiple unspecified drugs, medicaments and biological substances

        Inclusion term(s):

        • Multiple drug ingestion NOS
        • T50.911 Poisoning by multiple unspecified drugs, medicaments and biological substances, accidental (unintentional)
        • T50.912 Poisoning by multiple unspecified drugs, medicaments and biological substances, intentional self-harm
        • T50.913 Poisoning by multiple unspecified drugs, medicaments and biological substances, assault
        • T50.914 Poisoning by multiple unspecified drugs, medicaments and biological substances, undetermined
        • T50.915 Adverse effect of multiple unspecified drugs, medicaments and biological substances
        • T50.916 Underdosing of multiple unspecified drugs, medicaments and biological substances

      3. T50.99 Poisoning by, adverse effect of and underdosing of other drugs, medicaments and biological substances

        • T50.991 Poisoning by other drugs, medicaments and biological substances, accidental (unintentional)
        • T50.992 Poisoning by other drugs, medicaments and biological substances, intentional self-harm
        • T50.993 Poisoning by other drugs, medicaments and biological substances, assault
        • T50.994 Poisoning by other drugs, medicaments and biological substances, undetermined
        • T50.995 Adverse effect of other drugs, medicaments and biological substances
        • T50.996 Underdosing of other drugs, medicaments and biological substances

    11. T50.A Poisoning by, adverse effect of and underdosing of bacterial vaccines

      1. T50.A1 Poisoning by, adverse effect of and underdosing of pertussis vaccine, including combinations with a pertussis component

        • T50.A11 Poisoning by pertussis vaccine, including combinations with a pertussis component, accidental (unintentional)
        • T50.A12 Poisoning by pertussis vaccine, including combinations with a pertussis component, intentional self-harm
        • T50.A13 Poisoning by pertussis vaccine, including combinations with a pertussis component, assault
        • T50.A14 Poisoning by pertussis vaccine, including combinations with a pertussis component, undetermined
        • T50.A15 Adverse effect of pertussis vaccine, including combinations with a pertussis component
        • T50.A16 Underdosing of pertussis vaccine, including combinations with a pertussis component

      2. T50.A2 Poisoning by, adverse effect of and underdosing of mixed bacterial vaccines without a pertussis component

        • T50.A21 Poisoning by mixed bacterial vaccines without a pertussis component, accidental (unintentional)
        • T50.A22 Poisoning by mixed bacterial vaccines without a pertussis component, intentional self-harm
        • T50.A23 Poisoning by mixed bacterial vaccines without a pertussis component, assault
        • T50.A24 Poisoning by mixed bacterial vaccines without a pertussis component, undetermined
        • T50.A25 Adverse effect of mixed bacterial vaccines without a pertussis component
        • T50.A26 Underdosing of mixed bacterial vaccines without a pertussis component

      3. T50.A9 Poisoning by, adverse effect of and underdosing of other bacterial vaccines

        • T50.A91 Poisoning by other bacterial vaccines, accidental (unintentional)
        • T50.A92 Poisoning by other bacterial vaccines, intentional self-harm
        • T50.A93 Poisoning by other bacterial vaccines, assault
        • T50.A94 Poisoning by other bacterial vaccines, undetermined
        • T50.A95 Adverse effect of other bacterial vaccines
        • T50.A96 Underdosing of other bacterial vaccines

    12. T50.B Poisoning by, adverse effect of and underdosing of viral vaccines

      1. T50.B1 Poisoning by, adverse effect of and underdosing of smallpox vaccines

        • T50.B11 Poisoning by smallpox vaccines, accidental (unintentional)
        • T50.B12 Poisoning by smallpox vaccines, intentional self-harm
        • T50.B13 Poisoning by smallpox vaccines, assault
        • T50.B14 Poisoning by smallpox vaccines, undetermined
        • T50.B15 Adverse effect of smallpox vaccines
        • T50.B16 Underdosing of smallpox vaccines

      2. T50.B9 Poisoning by, adverse effect of and underdosing of other viral vaccines

        • T50.B91 Poisoning by other viral vaccines, accidental (unintentional)
        • T50.B92 Poisoning by other viral vaccines, intentional self-harm
        • T50.B93 Poisoning by other viral vaccines, assault
        • T50.B94 Poisoning by other viral vaccines, undetermined
        • T50.B95 Adverse effect of other viral vaccines
        • T50.B96 Underdosing of other viral vaccines

    13. T50.Z Poisoning by, adverse effect of and underdosing of other vaccines and biological substances

      1. T50.Z1 Poisoning by, adverse effect of and underdosing of immunoglobulin

        • T50.Z11 Poisoning by immunoglobulin, accidental (unintentional)
        • T50.Z12 Poisoning by immunoglobulin, intentional self-harm
        • T50.Z13 Poisoning by immunoglobulin, assault
        • T50.Z14 Poisoning by immunoglobulin, undetermined
        • T50.Z15 Adverse effect of immunoglobulin
        • T50.Z16 Underdosing of immunoglobulin

      2. T50.Z9 Poisoning by, adverse effect of and underdosing of other vaccines and biological substances

        • T50.Z91 Poisoning by other vaccines and biological substances, accidental (unintentional)
        • T50.Z92 Poisoning by other vaccines and biological substances, intentional self-harm
        • T50.Z93 Poisoning by other vaccines and biological substances, assault
        • T50.Z94 Poisoning by other vaccines and biological substances, undetermined
        • T50.Z95 Adverse effect of other vaccines and biological substances
        • T50.Z96 Underdosing of other vaccines and biological substances
Abbreviations used here:

NEC Not elsewhere classifiable
This abbreviation in the Tabular List represents “other specified”. When a specific code is not available for a condition, the Tabular List includes an NEC entry under a code to identify the code as the “other specified” code.

NOS Not otherwise specified
This abbreviation is the equivalent of unspecified.