1. Z17 Estrogen, and other hormones and factors receptor status

    Note: Use one code, as available, for each receptor: Z17.0, Z17.1, Z17.2-, Z17.3-

    1. Z17.0 Estrogen receptor positive status [ER+]

    2. Z17.1 Estrogen receptor negative status [ER-]

    3. Z17.2 Progesterone receptor status

      1. Z17.21 Progesterone receptor positive status

        Inclusion term(s):

        • PR+
      2. Z17.22 Progesterone receptor negative status

        Inclusion term(s):

        • PR-
    4. Z17.3 Human epidermal growth factor 2 receptor

      1. Z17.31 Human epidermal growth factor receptor 2 positive status

        Inclusion term(s):

        • HER2+
      2. Z17.32 Human epidermal growth factor receptor 2 negative status

        Inclusion term(s):

        • HER2-
    5. Z17.4 Combined receptor status

      Note: Assign a code from subcategory Z17.4- when only a combined receptor status is documented

      1. Z17.41 Hormone receptor positive

        Inclusion term(s):

        • HR+
        • Z17.410 Hormone receptor positive with human epidermal growth factor receptor 2 positive status

          Inclusion term(s):

          • HR+ with HER2+
        • Z17.411 Hormone receptor positive with human epidermal growth factor receptor 2 negative status

          Inclusion term(s):

          • HR+ with HER2-
      2. Z17.42 Hormone receptor negative

        Inclusion term(s):

        • HR-
        • Z17.420 Hormone receptor negative with human epidermal growth factor receptor 2 positive status

          Inclusion term(s):

          • HR- with HER2+
        • Z17.421 Hormone receptor negative with human epidermal growth factor receptor 2 negative status

          Inclusion term(s):

          • HR- with HER2-
          • TNBC
          • Triple negative breast cancer
Abbreviations used here:

NEC Not elsewhere classifiable
This abbreviation in the Tabular List represents “other specified”. When a specific code is not available for a condition, the Tabular List includes an NEC entry under a code to identify the code as the “other specified” code.

NOS Not otherwise specified
This abbreviation is the equivalent of unspecified.