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Substance Poisoning
Accidental (unintentional)
Poisoning
Intentional (self-harm)
Poisoning
Assault
Poisoning
Undetermined
Adverse
Effect
Underdosing
Anisotropine methyl-bromide T44.3X1 T44.3X2 T44.3X3 T44.3X4 T44.3X5 T44.3X6
Anistreplase T45.611 T45.612 T45.613 T45.614 T45.615 T45.616
Anorexiant (central) T50.5X1 T50.5X2 T50.5X3 T50.5X4 T50.5X5 T50.5X6
Anorexic agents T50.5X1 T50.5X2 T50.5X3 T50.5X4 T50.5X5 T50.5X6
Ansamycin T36.6X1 T36.6X2 T36.6X3 T36.6X4 T36.6X5 T36.6X6
Ant (bite) (sting) T63.421 T63.422 T63.423 T63.424 -- --
Antabuse T50.6X1 T50.6X2 T50.6X3 T50.6X4 T50.6X5 T50.6X6
Antacid NEC T47.1X1 T47.1X2 T47.1X3 T47.1X4 T47.1X5 T47.1X6
Antagonist
– Aldosterone T50.0X1 T50.0X2 T50.0X3 T50.0X4 T50.0X5 T50.0X6
– alpha-adrenoreceptor T44.6X1 T44.6X2 T44.6X3 T44.6X4 T44.6X5 T44.6X6
– anticoagulant T45.7X1 T45.7X2 T45.7X3 T45.7X4 T45.7X5 T45.7X6
– beta-adrenoreceptor T44.7X1 T44.7X2 T44.7X3 T44.7X4 T44.7X5 T44.7X6
– extrapyramidal NEC T44.3X1 T44.3X2 T44.3X3 T44.3X4 T44.3X5 T44.3X6
– folic acid T45.1X1 T45.1X2 T45.1X3 T45.1X4 T45.1X5 T45.1X6
– H2 receptor T47.0X1 T47.0X2 T47.0X3 T47.0X4 T47.0X5 T47.0X6
– heavy metal T45.8X1 T45.8X2 T45.8X3 T45.8X4 T45.8X5 T45.8X6
– narcotic analgesic T50.7X1 T50.7X2 T50.7X3 T50.7X4 T50.7X5 T50.7X6
– opiate T50.7X1 T50.7X2 T50.7X3 T50.7X4 T50.7X5 T50.7X6
– pyrimidine T45.1X1 T45.1X2 T45.1X3 T45.1X4 T45.1X5 T45.1X6
– serotonin T46.5X1 T46.5X2 T46.5X3 T46.5X4 T46.5X5 T46.5X6
Antazolin (e) T45.0X1 T45.0X2 T45.0X3 T45.0X4 T45.0X5 T45.0X6

The occurrence of drug toxicity is classified in ICD-10-CM as follows:

Adverse Effect

When coding an adverse effect of a drug that has been correctly prescribed and properly administered, assign the appropriate code for the nature of the adverse effect followed by the appropriate code for the adverse effect of the drug (T36-T50). The code for the drug should have a 5th or 6th character “5” (for example T36.0X5-) Examples of the nature of an adverse effect are tachycardia, delirium, gastrointestinal hemorrhaging, vomiting, hypokalemia, hepatitis, renal failure, or respiratory failure.

Poisoning

When coding a poisoning or reaction to the improper use of a medication (e.g., overdose, wrong substance given or taken in error, wrong route of administration), first assign the appropriate code from categories T36-T50. The poisoning codes have an associated intent as their 5th or 6th character (accidental, intentional self-harm, assault and undetermined. If the intent of the poisoning is unknown or unspecified, code the intent as accidental intent. The undetermined intent is only for use if the documentation in the record specifies that the intent cannot be determined. Use additional code(s) for all manifestations of poisonings.

If there is also a diagnosis of abuse or dependence of the substance, the abuse or dependence is assigned as an additional code.

Examples of poisoning include:
  • Error was made in drug prescription
    Errors made in drug prescription or in the administration of the drug by provider, nurse, patient, or other person.
  • Overdose of a drug intentionally taken
    If an overdose of a drug was intentionally taken or administered and resulted in drug toxicity, it would be coded as a poisoning.
  • Nonprescribed drug taken with correctly prescribed and properly administered drug
    If a nonprescribed drug or medicinal agent was taken in combination with a correctly prescribed and properly administered drug, any drug toxicity or other reaction resulting from the interaction of the two drugs would be classified as a poisoning.
  • Interaction of drug(s) and alcohol
    When a reaction results from the interaction of a drug(s) and alcohol, this would be classified as poisoning.
Underdosing

Underdosing refers to taking less of a medication than is prescribed by a provider or a manufacturer's instruction. Discontinuing the use of a prescribed medication on the patient's own initiative (not directed by the patient's provider) is also classified as an underdosing. For underdosing, assign the code from categories T36-T50 (fifth or sixth character “6”).

Codes for underdosing should never be assigned as principal or first-listed codes. If a patient has a relapse or exacerbation of the medical condition for which the drug is prescribed because of the reduction in dose, then the medical condition itself should be coded.

Noncompliance (Z91.12-, Z91.13- and Z91.14-) or complication of care (Y63.6-Y63.9) codes are to be used with an underdosing code to indicate intent, if known.

Toxic Effects

When a harmful substance is ingested or comes in contact with a person, this is classified as a toxic effect. The toxic effect codes are in categories T51-T65.

Toxic effect codes have an associated intent: accidental, intentional self-harm, assault and undetermined.