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Substance Poisoning
Accidental (unintentional)
Poisoning
Intentional (self-harm)
Poisoning
Assault
Poisoning
Undetermined
Adverse
Effect
Underdosing
Anticonvulsant T42.71 T42.72 T42.73 T42.74 T42.75 T42.76
– barbiturate T42.3X1 T42.3X2 T42.3X3 T42.3X4 T42.3X5 T42.3X6
– combination (with barbiturate) T42.3X1 T42.3X2 T42.3X3 T42.3X4 T42.3X5 T42.3X6
– hydantoin T42.0X1 T42.0X2 T42.0X3 T42.0X4 T42.0X5 T42.0X6
– hypnotic NEC T42.6X1 T42.6X2 T42.6X3 T42.6X4 T42.6X5 T42.6X6
– oxazolidinedione T42.2X1 T42.2X2 T42.2X3 T42.2X4 T42.2X5 T42.2X6
– pyrimidinedione T42.6X1 T42.6X2 T42.6X3 T42.6X4 T42.6X5 T42.6X6
– specified NEC T42.6X1 T42.6X2 T42.6X3 T42.6X4 T42.6X5 T42.6X6
– succinimide T42.2X1 T42.2X2 T42.2X3 T42.2X4 T42.2X5 T42.2X6
Anti-D immunoglobulin (human) T50.Z11 T50.Z12 T50.Z13 T50.Z14 T50.Z15 T50.Z16
Antidepressant T43.201 T43.202 T43.203 T43.204 T43.205 T43.206
– monoamine oxidase inhibitor T43.1X1 T43.1X2 T43.1X3 T43.1X4 T43.1X5 T43.1X6
– selective serotonin norepinephrine reuptake inhibitor T43.211 T43.212 T43.213 T43.214 T43.215 T43.216
– selective serotonin reuptake inhibitor T43.221 T43.222 T43.223 T43.224 T43.225 T43.226
– specified NEC T43.291 T43.292 T43.293 T43.294 T43.295 T43.296
– tetracyclic T43.021 T43.022 T43.023 T43.024 T43.025 T43.026
– triazolopyridine T43.211 T43.212 T43.213 T43.214 T43.215 T43.216
– tricyclic T43.011 T43.012 T43.013 T43.014 T43.015 T43.016
Antidiabetic NEC T38.3X1 T38.3X2 T38.3X3 T38.3X4 T38.3X5 T38.3X6
– biguanide T38.3X1 T38.3X2 T38.3X3 T38.3X4 T38.3X5 T38.3X6
– – and sulfonyl combined T38.3X1 T38.3X2 T38.3X3 T38.3X4 T38.3X5 T38.3X6
– combined T38.3X1 T38.3X2 T38.3X3 T38.3X4 T38.3X5 T38.3X6
– sulfonylurea T38.3X1 T38.3X2 T38.3X3 T38.3X4 T38.3X5 T38.3X6
Antidiarrheal drug NEC T47.6X1 T47.6X2 T47.6X3 T47.6X4 T47.6X5 T47.6X6
– absorbent T47.6X1 T47.6X2 T47.6X3 T47.6X4 T47.6X5 T47.6X6
Antidiphtheria serum T50.Z11 T50.Z12 T50.Z13 T50.Z14 T50.Z15 T50.Z16
Antidiuretic hormone T38.891 T38.892 T38.893 T38.894 T38.895 T38.896
Antidote NEC T50.6X1 T50.6X2 T50.6X3 T50.6X4 T50.6X5 T50.6X6
– heavy metal T45.8X1 T45.8X2 T45.8X3 T45.8X4 T45.8X5 T45.8X6
Antidysrhythmic NEC T46.2X1 T46.2X2 T46.2X3 T46.2X4 T46.2X5 T46.2X6
Antiemetic drug T45.0X1 T45.0X2 T45.0X3 T45.0X4 T45.0X5 T45.0X6

The occurrence of drug toxicity is classified in ICD-10-CM as follows:

Adverse Effect

When coding an adverse effect of a drug that has been correctly prescribed and properly administered, assign the appropriate code for the nature of the adverse effect followed by the appropriate code for the adverse effect of the drug (T36-T50). The code for the drug should have a 5th or 6th character “5” (for example T36.0X5-) Examples of the nature of an adverse effect are tachycardia, delirium, gastrointestinal hemorrhaging, vomiting, hypokalemia, hepatitis, renal failure, or respiratory failure.

Poisoning

When coding a poisoning or reaction to the improper use of a medication (e.g., overdose, wrong substance given or taken in error, wrong route of administration), first assign the appropriate code from categories T36-T50. The poisoning codes have an associated intent as their 5th or 6th character (accidental, intentional self-harm, assault and undetermined. If the intent of the poisoning is unknown or unspecified, code the intent as accidental intent. The undetermined intent is only for use if the documentation in the record specifies that the intent cannot be determined. Use additional code(s) for all manifestations of poisonings.

If there is also a diagnosis of abuse or dependence of the substance, the abuse or dependence is assigned as an additional code.

Examples of poisoning include:
  • Error was made in drug prescription
    Errors made in drug prescription or in the administration of the drug by provider, nurse, patient, or other person.
  • Overdose of a drug intentionally taken
    If an overdose of a drug was intentionally taken or administered and resulted in drug toxicity, it would be coded as a poisoning.
  • Nonprescribed drug taken with correctly prescribed and properly administered drug
    If a nonprescribed drug or medicinal agent was taken in combination with a correctly prescribed and properly administered drug, any drug toxicity or other reaction resulting from the interaction of the two drugs would be classified as a poisoning.
  • Interaction of drug(s) and alcohol
    When a reaction results from the interaction of a drug(s) and alcohol, this would be classified as poisoning.
Underdosing

Underdosing refers to taking less of a medication than is prescribed by a provider or a manufacturer's instruction. Discontinuing the use of a prescribed medication on the patient's own initiative (not directed by the patient's provider) is also classified as an underdosing. For underdosing, assign the code from categories T36-T50 (fifth or sixth character “6”).

Codes for underdosing should never be assigned as principal or first-listed codes. If a patient has a relapse or exacerbation of the medical condition for which the drug is prescribed because of the reduction in dose, then the medical condition itself should be coded.

Noncompliance (Z91.12-, Z91.13- and Z91.14-) or complication of care (Y63.6-Y63.9) codes are to be used with an underdosing code to indicate intent, if known.

Toxic Effects

When a harmful substance is ingested or comes in contact with a person, this is classified as a toxic effect. The toxic effect codes are in categories T51-T65.

Toxic effect codes have an associated intent: accidental, intentional self-harm, assault and undetermined.