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Substance Poisoning
Accidental (unintentional)
Poisoning
Intentional (self-harm)
Poisoning
Assault
Poisoning
Undetermined
Adverse
Effect
Underdosing
Antihallucinogen T43.501 T43.502 T43.503 T43.504 T43.505 T43.506
Antihelmintics T37.4X1 T37.4X2 T37.4X3 T37.4X4 T37.4X5 T37.4X6
Antihemophilic
– factor T45.8X1 T45.8X2 T45.8X3 T45.8X4 T45.8X5 T45.8X6
– fraction T45.8X1 T45.8X2 T45.8X3 T45.8X4 T45.8X5 T45.8X6
– globulin concentrate T45.7X1 T45.7X2 T45.7X3 T45.7X4 T45.7X5 T45.7X6
– human plasma T45.8X1 T45.8X2 T45.8X3 T45.8X4 T45.8X5 T45.8X6
– plasma, dried T45.7X1 T45.7X2 T45.7X3 T45.7X4 T45.7X5 T45.7X6
Antihemorrhoidal preparation T49.2X1 T49.2X2 T49.2X3 T49.2X4 T49.2X5 T49.2X6
Antiheparin drug T45.7X1 T45.7X2 T45.7X3 T45.7X4 T45.7X5 T45.7X6
Antihistamine T45.0X1 T45.0X2 T45.0X3 T45.0X4 T45.0X5 T45.0X6
Antihookworm drug T37.4X1 T37.4X2 T37.4X3 T37.4X4 T37.4X5 T37.4X6
Anti-human lymphocytic globulin T50.Z11 T50.Z12 T50.Z13 T50.Z14 T50.Z15 T50.Z16
Antihyperlipidemic drug T46.6X1 T46.6X2 T46.6X3 T46.6X4 T46.6X5 T46.6X6
Antihypertensive drug NEC T46.5X1 T46.5X2 T46.5X3 T46.5X4 T46.5X5 T46.5X6

The occurrence of drug toxicity is classified in ICD-10-CM as follows:

Adverse Effect

When coding an adverse effect of a drug that has been correctly prescribed and properly administered, assign the appropriate code for the nature of the adverse effect followed by the appropriate code for the adverse effect of the drug (T36-T50). The code for the drug should have a 5th or 6th character “5” (for example T36.0X5-) Examples of the nature of an adverse effect are tachycardia, delirium, gastrointestinal hemorrhaging, vomiting, hypokalemia, hepatitis, renal failure, or respiratory failure.

Poisoning

When coding a poisoning or reaction to the improper use of a medication (e.g., overdose, wrong substance given or taken in error, wrong route of administration), first assign the appropriate code from categories T36-T50. The poisoning codes have an associated intent as their 5th or 6th character (accidental, intentional self-harm, assault and undetermined. If the intent of the poisoning is unknown or unspecified, code the intent as accidental intent. The undetermined intent is only for use if the documentation in the record specifies that the intent cannot be determined. Use additional code(s) for all manifestations of poisonings.

If there is also a diagnosis of abuse or dependence of the substance, the abuse or dependence is assigned as an additional code.

Examples of poisoning include:
  • Error was made in drug prescription
    Errors made in drug prescription or in the administration of the drug by provider, nurse, patient, or other person.
  • Overdose of a drug intentionally taken
    If an overdose of a drug was intentionally taken or administered and resulted in drug toxicity, it would be coded as a poisoning.
  • Nonprescribed drug taken with correctly prescribed and properly administered drug
    If a nonprescribed drug or medicinal agent was taken in combination with a correctly prescribed and properly administered drug, any drug toxicity or other reaction resulting from the interaction of the two drugs would be classified as a poisoning.
  • Interaction of drug(s) and alcohol
    When a reaction results from the interaction of a drug(s) and alcohol, this would be classified as poisoning.
Underdosing

Underdosing refers to taking less of a medication than is prescribed by a provider or a manufacturer's instruction. Discontinuing the use of a prescribed medication on the patient's own initiative (not directed by the patient's provider) is also classified as an underdosing. For underdosing, assign the code from categories T36-T50 (fifth or sixth character “6”).

Codes for underdosing should never be assigned as principal or first-listed codes. If a patient has a relapse or exacerbation of the medical condition for which the drug is prescribed because of the reduction in dose, then the medical condition itself should be coded.

Noncompliance (Z91.12-, Z91.13- and Z91.14-) or complication of care (Y63.6-Y63.9) codes are to be used with an underdosing code to indicate intent, if known.

Toxic Effects

When a harmful substance is ingested or comes in contact with a person, this is classified as a toxic effect. The toxic effect codes are in categories T51-T65.

Toxic effect codes have an associated intent: accidental, intentional self-harm, assault and undetermined.