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Substance Poisoning
Accidental (unintentional)
Poisoning
Intentional (self-harm)
Poisoning
Assault
Poisoning
Undetermined
Adverse
Effect
Underdosing
Anti-infective NEC T37.91 T37.92 T37.93 T37.94 T37.95 T37.96
– anthelmintic T37.4X1 T37.4X2 T37.4X3 T37.4X4 T37.4X5 T37.4X6
– antibiotics T36.91 T36.92 T36.93 T36.94 T36.95 T36.96
– – specified NEC T36.8X1 T36.8X2 T36.8X3 T36.8X4 T36.8X5 T36.8X6
– antimalarial T37.2X1 T37.2X2 T37.2X3 T37.2X4 T37.2X5 T37.2X6
– antimycobacterial NEC T37.1X1 T37.1X2 T37.1X3 T37.1X4 T37.1X5 T37.1X6
– – antibiotics T36.5X1 T36.5X2 T36.5X3 T36.5X4 T36.5X5 T36.5X6
– antiprotozoal NEC T37.3X1 T37.3X2 T37.3X3 T37.3X4 T37.3X5 T37.3X6
– – blood T37.2X1 T37.2X2 T37.2X3 T37.2X4 T37.2X5 T37.2X6
– antiviral T37.5X1 T37.5X2 T37.5X3 T37.5X4 T37.5X5 T37.5X6
– arsenical T37.8X1 T37.8X2 T37.8X3 T37.8X4 T37.8X5 T37.8X6
– bismuth, local T49.0X1 T49.0X2 T49.0X3 T49.0X4 T49.0X5 T49.0X6
– ENT T49.6X1 T49.6X2 T49.6X3 T49.6X4 T49.6X5 T49.6X6
– eye NEC T49.5X1 T49.5X2 T49.5X3 T49.5X4 T49.5X5 T49.5X6
– heavy metals NEC T37.8X1 T37.8X2 T37.8X3 T37.8X4 T37.8X5 T37.8X6
– local NEC T49.0X1 T49.0X2 T49.0X3 T49.0X4 T49.0X5 T49.0X6
– – specified NEC T49.0X1 T49.0X2 T49.0X3 T49.0X4 T49.0X5 T49.0X6
– mixed T37.91 T37.92 T37.93 T37.94 T37.95 T37.96
– ophthalmic preparation T49.5X1 T49.5X2 T49.5X3 T49.5X4 T49.5X5 T49.5X6
– topical NEC T49.0X1 T49.0X2 T49.0X3 T49.0X4 T49.0X5 T49.0X6
Anti-inflammatory drug NEC T39.391 T39.392 T39.393 T39.394 T39.395 T39.396
– local T49.0X1 T49.0X2 T49.0X3 T49.0X4 T49.0X5 T49.0X6
– nonsteroidal NEC T39.391 T39.392 T39.393 T39.394 T39.395 T39.396
– – propionic acid derivative T39.311 T39.312 T39.313 T39.314 T39.315 T39.316
– specified NEC T39.391 T39.392 T39.393 T39.394 T39.395 T39.396
Antikaluretic T50.3X1 T50.3X2 T50.3X3 T50.3X4 T50.3X5 T50.3X6
Antiknock (tetraethyl lead) T56.0X1 T56.0X2 T56.0X3 T56.0X4 -- --
Antilipemic drug NEC T46.6X1 T46.6X2 T46.6X3 T46.6X4 T46.6X5 T46.6X6
Antimalarial T37.2X1 T37.2X2 T37.2X3 T37.2X4 T37.2X5 T37.2X6
– prophylactic NEC T37.2X1 T37.2X2 T37.2X3 T37.2X4 T37.2X5 T37.2X6
– pyrimidine derivative T37.2X1 T37.2X2 T37.2X3 T37.2X4 T37.2X5 T37.2X6
Antimetabolite T45.1X1 T45.1X2 T45.1X3 T45.1X4 T45.1X5 T45.1X6
Antimitotic agent T45.1X1 T45.1X2 T45.1X3 T45.1X4 T45.1X5 T45.1X6
Antimony (compounds) (vapor) T56.891 T56.892 T56.893 T56.894 -- --
– anti-infectives T37.8X1 T37.8X2 T37.8X3 T37.8X4 T37.8X5 T37.8X6
– dimercaptosuccinate T37.3X1 T37.3X2 T37.3X3 T37.3X4 T37.3X5 T37.3X6
– hydride T56.891 T56.892 T56.893 T56.894 -- --
– pesticide (vapor) T60.8X1 T60.8X2 T60.8X3 T60.8X4 -- --
– potassium (sodium) T37.8X1 T37.8X2 T37.8X3 T37.8X4 T37.8X5 T37.8X6
– sodium dimercaptosuccinate T37.3X1 T37.3X2 T37.3X3 T37.3X4 T37.3X5 T37.3X6
– tartrated T37.8X1 T37.8X2 T37.8X3 T37.8X4 T37.8X5 T37.8X6
Antimuscarinic NEC T44.3X1 T44.3X2 T44.3X3 T44.3X4 T44.3X5 T44.3X6

The occurrence of drug toxicity is classified in ICD-10-CM as follows:

Adverse Effect

When coding an adverse effect of a drug that has been correctly prescribed and properly administered, assign the appropriate code for the nature of the adverse effect followed by the appropriate code for the adverse effect of the drug (T36-T50). The code for the drug should have a 5th or 6th character “5” (for example T36.0X5-) Examples of the nature of an adverse effect are tachycardia, delirium, gastrointestinal hemorrhaging, vomiting, hypokalemia, hepatitis, renal failure, or respiratory failure.

Poisoning

When coding a poisoning or reaction to the improper use of a medication (e.g., overdose, wrong substance given or taken in error, wrong route of administration), first assign the appropriate code from categories T36-T50. The poisoning codes have an associated intent as their 5th or 6th character (accidental, intentional self-harm, assault and undetermined. If the intent of the poisoning is unknown or unspecified, code the intent as accidental intent. The undetermined intent is only for use if the documentation in the record specifies that the intent cannot be determined. Use additional code(s) for all manifestations of poisonings.

If there is also a diagnosis of abuse or dependence of the substance, the abuse or dependence is assigned as an additional code.

Examples of poisoning include:
  • Error was made in drug prescription
    Errors made in drug prescription or in the administration of the drug by provider, nurse, patient, or other person.
  • Overdose of a drug intentionally taken
    If an overdose of a drug was intentionally taken or administered and resulted in drug toxicity, it would be coded as a poisoning.
  • Nonprescribed drug taken with correctly prescribed and properly administered drug
    If a nonprescribed drug or medicinal agent was taken in combination with a correctly prescribed and properly administered drug, any drug toxicity or other reaction resulting from the interaction of the two drugs would be classified as a poisoning.
  • Interaction of drug(s) and alcohol
    When a reaction results from the interaction of a drug(s) and alcohol, this would be classified as poisoning.
Underdosing

Underdosing refers to taking less of a medication than is prescribed by a provider or a manufacturer's instruction. Discontinuing the use of a prescribed medication on the patient's own initiative (not directed by the patient's provider) is also classified as an underdosing. For underdosing, assign the code from categories T36-T50 (fifth or sixth character “6”).

Codes for underdosing should never be assigned as principal or first-listed codes. If a patient has a relapse or exacerbation of the medical condition for which the drug is prescribed because of the reduction in dose, then the medical condition itself should be coded.

Noncompliance (Z91.12-, Z91.13- and Z91.14-) or complication of care (Y63.6-Y63.9) codes are to be used with an underdosing code to indicate intent, if known.

Toxic Effects

When a harmful substance is ingested or comes in contact with a person, this is classified as a toxic effect. The toxic effect codes are in categories T51-T65.

Toxic effect codes have an associated intent: accidental, intentional self-harm, assault and undetermined.