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Substance Poisoning
Accidental (unintentional)
Poisoning
Intentional (self-harm)
Poisoning
Assault
Poisoning
Undetermined
Adverse
Effect
Underdosing
Antiseptics (external) (medicinal) T49.0X1 T49.0X2 T49.0X3 T49.0X4 T49.0X5 T49.0X6
Antistine T45.0X1 T45.0X2 T45.0X3 T45.0X4 T45.0X5 T45.0X6
Antitapeworm drug T37.4X1 T37.4X2 T37.4X3 T37.4X4 T37.4X5 T37.4X6
Antitetanus immunoglobulin T50.Z11 T50.Z12 T50.Z13 T50.Z14 T50.Z15 T50.Z16
Antithrombotic T45.521 T45.522 T45.523 T45.524 T45.525 T45.526
Antithyroid drug NEC T38.2X1 T38.2X2 T38.2X3 T38.2X4 T38.2X5 T38.2X6
Antitoxin T50.Z11 T50.Z12 T50.Z13 T50.Z14 T50.Z15 T50.Z16
– diphtheria T50.Z11 T50.Z12 T50.Z13 T50.Z14 T50.Z15 T50.Z16
– gas gangrene T50.Z11 T50.Z12 T50.Z13 T50.Z14 T50.Z15 T50.Z16
– tetanus T50.Z11 T50.Z12 T50.Z13 T50.Z14 T50.Z15 T50.Z16
Antitrichomonal drug T37.3X1 T37.3X2 T37.3X3 T37.3X4 T37.3X5 T37.3X6
Antituberculars T37.1X1 T37.1X2 T37.1X3 T37.1X4 T37.1X5 T37.1X6
– antibiotics T36.5X1 T36.5X2 T36.5X3 T36.5X4 T36.5X5 T36.5X6
Antitussive NEC T48.3X1 T48.3X2 T48.3X3 T48.3X4 T48.3X5 T48.3X6
– codeine mixture T40.2X1 T40.2X2 T40.2X3 T40.2X4 T40.2X5 T40.2X6
– opiate T40.2X1 T40.2X2 T40.2X3 T40.2X4 T40.2X5 T40.2X6

The occurrence of drug toxicity is classified in ICD-10-CM as follows:

Adverse Effect

When coding an adverse effect of a drug that has been correctly prescribed and properly administered, assign the appropriate code for the nature of the adverse effect followed by the appropriate code for the adverse effect of the drug (T36-T50). The code for the drug should have a 5th or 6th character “5” (for example T36.0X5-) Examples of the nature of an adverse effect are tachycardia, delirium, gastrointestinal hemorrhaging, vomiting, hypokalemia, hepatitis, renal failure, or respiratory failure.

Poisoning

When coding a poisoning or reaction to the improper use of a medication (e.g., overdose, wrong substance given or taken in error, wrong route of administration), first assign the appropriate code from categories T36-T50. The poisoning codes have an associated intent as their 5th or 6th character (accidental, intentional self-harm, assault and undetermined. If the intent of the poisoning is unknown or unspecified, code the intent as accidental intent. The undetermined intent is only for use if the documentation in the record specifies that the intent cannot be determined. Use additional code(s) for all manifestations of poisonings.

If there is also a diagnosis of abuse or dependence of the substance, the abuse or dependence is assigned as an additional code.

Examples of poisoning include:
  • Error was made in drug prescription
    Errors made in drug prescription or in the administration of the drug by provider, nurse, patient, or other person.
  • Overdose of a drug intentionally taken
    If an overdose of a drug was intentionally taken or administered and resulted in drug toxicity, it would be coded as a poisoning.
  • Nonprescribed drug taken with correctly prescribed and properly administered drug
    If a nonprescribed drug or medicinal agent was taken in combination with a correctly prescribed and properly administered drug, any drug toxicity or other reaction resulting from the interaction of the two drugs would be classified as a poisoning.
  • Interaction of drug(s) and alcohol
    When a reaction results from the interaction of a drug(s) and alcohol, this would be classified as poisoning.
Underdosing

Underdosing refers to taking less of a medication than is prescribed by a provider or a manufacturer's instruction. Discontinuing the use of a prescribed medication on the patient's own initiative (not directed by the patient's provider) is also classified as an underdosing. For underdosing, assign the code from categories T36-T50 (fifth or sixth character “6”).

Codes for underdosing should never be assigned as principal or first-listed codes. If a patient has a relapse or exacerbation of the medical condition for which the drug is prescribed because of the reduction in dose, then the medical condition itself should be coded.

Noncompliance (Z91.12-, Z91.13- and Z91.14-) or complication of care (Y63.6-Y63.9) codes are to be used with an underdosing code to indicate intent, if known.

Toxic Effects

When a harmful substance is ingested or comes in contact with a person, this is classified as a toxic effect. The toxic effect codes are in categories T51-T65.

Toxic effect codes have an associated intent: accidental, intentional self-harm, assault and undetermined.