ICD-10-CM — Chapter 2

Neoplasms - Contains the codes for most benign and all malignant neoplasms. Certain benign neoplasms, such as prostatic adenomas, may be found in the specific body system chapters.

Tabular List

Find your ICD-10-CM code by first selecting the most applicable chapter



Neoplasms

- Contains the codes for most benign and all malignant neoplasms. Certain benign neoplasms, such as prostatic adenomas, may be found in the specific body system chapters.

Note:
Functional activity
All neoplasms are classified in this chapter, whether they are functionally active or not. An additional code from Chapter 4 may be used, to identify functional activity associated with any neoplasm.

Morphology [Histology]
Chapter 2 classifies neoplasms primarily by site (topography), with broad groupings for behavior, malignant, in situ, benign, etc. The Table of Neoplasms should be used to identify the correct topography code. In a few cases, such as for malignant melanoma and certain neuroendocrine tumors, the morphology (histologic type) is included in the category and codes.

Primary malignant neoplasms overlapping site boundaries
A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified to the subcategory/code .8 ('overlapping lesion'), unless the combination is specifically indexed elsewhere. For multiple neoplasms of the same site that are not contiguous, such as tumors in different quadrants of the same breast, codes for each site should be assigned.

Malignant neoplasm of ectopic tissue
Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ectopic pancreatic malignant neoplasms are coded to pancreas, unspecified (C25.9).

Expand All Chapter #2 contains the following ICD-10-CM sections:
  • C00 Malignant neoplasm of lip

  • C01 Malignant neoplasm of base of tongue

    Inclusion term(s):

    • Malignant neoplasm of dorsal surface of base of tongue
    • Malignant neoplasm of fixed part of tongue NOS
    • Malignant neoplasm of posterior third of tongue
  • C02 Malignant neoplasm of other and unspecified parts of tongue

  • C03 Malignant neoplasm of gum

  • C04 Malignant neoplasm of floor of mouth

  • C05 Malignant neoplasm of palate

  • C06 Malignant neoplasm of other and unspecified parts of mouth

  • C07 Malignant neoplasm of parotid gland

  • C08 Malignant neoplasm of other and unspecified major salivary glands

  • C09 Malignant neoplasm of tonsil

  • C10 Malignant neoplasm of oropharynx

  • C11 Malignant neoplasm of nasopharynx

  • C12 Malignant neoplasm of pyriform sinus

    Inclusion term(s):

    • Malignant neoplasm of pyriform fossa
  • C13 Malignant neoplasm of hypopharynx

  • C14 Malignant neoplasm of other and ill-defined sites in the lip, oral cavity and pharynx

Excludes1

  • Kaposi's sarcoma of gastrointestinal sites (C46.4)

Excludes2

  • gastrointestinal stromal tumors (C49.A-)
  • C15 Malignant neoplasm of esophagus

  • C16 Malignant neoplasm of stomach

  • C17 Malignant neoplasm of small intestine

  • C18 Malignant neoplasm of colon

  • C19 Malignant neoplasm of rectosigmoid junction

    Inclusion term(s):

    • Malignant neoplasm of colon with rectum
    • Malignant neoplasm of rectosigmoid (colon)
  • C20 Malignant neoplasm of rectum

    Inclusion term(s):

    • Malignant neoplasm of rectal ampulla
  • C21 Malignant neoplasm of anus and anal canal

  • C22 Malignant neoplasm of liver and intrahepatic bile ducts

  • C23 Malignant neoplasm of gallbladder

  • C24 Malignant neoplasm of other and unspecified parts of biliary tract

  • C25 Malignant neoplasm of pancreas

  • C26 Malignant neoplasm of other and ill-defined digestive organs

Includes:

  • malignant neoplasm of middle ear

Excludes1

  • mesothelioma (C45.-)
  • C30 Malignant neoplasm of nasal cavity and middle ear

  • C31 Malignant neoplasm of accessory sinuses

  • C32 Malignant neoplasm of larynx

  • C33 Malignant neoplasm of trachea

  • C34 Malignant neoplasm of bronchus and lung

  • C37 Malignant neoplasm of thymus

  • C38 Malignant neoplasm of heart, mediastinum and pleura

  • C39 Malignant neoplasm of other and ill-defined sites in the respiratory system and intrathoracic organs

Includes:

  • malignant neoplasm of cartilage (articular) (joint)
  • malignant neoplasm of periosteum

Excludes1

  • malignant neoplasm of bone marrow NOS (C96.9)
  • malignant neoplasm of synovia (C49.-)
  • C40 Malignant neoplasm of bone and articular cartilage of limbs

  • C41 Malignant neoplasm of bone and articular cartilage of other and unspecified sites

  • C43 Malignant melanoma of skin

  • C44 Other and unspecified malignant neoplasm of skin

  • C4A Merkel cell carcinoma

  • C45 Mesothelioma

  • C46 Kaposi's sarcoma

  • C47 Malignant neoplasm of peripheral nerves and autonomic nervous system

  • C48 Malignant neoplasm of retroperitoneum and peritoneum

  • C49 Malignant neoplasm of other connective and soft tissue

  • C50 Malignant neoplasm of breast

Includes:

  • malignant neoplasm of skin of female genital organs
  • C51 Malignant neoplasm of vulva

  • C52 Malignant neoplasm of vagina

  • C53 Malignant neoplasm of cervix uteri

  • C54 Malignant neoplasm of corpus uteri

  • C55 Malignant neoplasm of uterus, part unspecified

  • C56 Malignant neoplasm of ovary

  • C57 Malignant neoplasm of other and unspecified female genital organs

  • C58 Malignant neoplasm of placenta

Includes:

  • malignant neoplasm of skin of male genital organs
  • C60 Malignant neoplasm of penis

  • C61 Malignant neoplasm of prostate

  • C62 Malignant neoplasm of testis

  • C63 Malignant neoplasm of other and unspecified male genital organs

  • C64 Malignant neoplasm of kidney, except renal pelvis

  • C65 Malignant neoplasm of renal pelvis

  • C66 Malignant neoplasm of ureter

  • C67 Malignant neoplasm of bladder

  • C68 Malignant neoplasm of other and unspecified urinary organs

  • C69 Malignant neoplasm of eye and adnexa

  • C70 Malignant neoplasm of meninges

  • C71 Malignant neoplasm of brain

  • C72 Malignant neoplasm of spinal cord, cranial nerves and other parts of central nervous system

  • C73 Malignant neoplasm of thyroid gland

  • C74 Malignant neoplasm of adrenal gland

  • C75 Malignant neoplasm of other endocrine glands and related structures

  • C76 Malignant neoplasm of other and ill-defined sites

  • C77 Secondary and unspecified malignant neoplasm of lymph nodes

  • C78 Secondary malignant neoplasm of respiratory and digestive organs

  • C79 Secondary malignant neoplasm of other and unspecified sites

  • C80 Malignant neoplasm without specification of site

  • C7A Malignant neuroendocrine tumors

  • C7B Secondary neuroendocrine tumors

Excludes2

  • Kaposi's sarcoma of lymph nodes (C46.3)
  • secondary and unspecified neoplasm of lymph nodes (C77.-)
  • secondary neoplasm of bone marrow (C79.52)
  • secondary neoplasm of spleen (C78.89)
  • C81 Hodgkin lymphoma

  • C82 Follicular lymphoma

  • C83 Non-follicular lymphoma

  • C84 Mature T/NK-cell lymphomas

  • C85 Other specified and unspecified types of non-Hodgkin lymphoma

  • C86 Other specified types of T/NK-cell lymphoma

  • C88 Malignant immunoproliferative diseases and certain other B-cell lymphomas

  • C90 Multiple myeloma and malignant plasma cell neoplasms

  • C91 Lymphoid leukemia

  • C92 Myeloid leukemia

  • C93 Monocytic leukemia

  • C94 Other leukemias of specified cell type

  • C95 Leukemia of unspecified cell type

  • C96 Other and unspecified malignant neoplasms of lymphoid, hematopoietic and related tissue

Includes:

  • Bowen's disease
  • erythroplasia
  • grade III intraepithelial neoplasia
  • Queyrat's erythroplasia
  • D00 Carcinoma in situ of oral cavity, esophagus and stomach

  • D01 Carcinoma in situ of other and unspecified digestive organs

  • D02 Carcinoma in situ of middle ear and respiratory system

  • D03 Melanoma in situ

  • D04 Carcinoma in situ of skin

  • D05 Carcinoma in situ of breast

  • D06 Carcinoma in situ of cervix uteri

  • D07 Carcinoma in situ of other and unspecified genital organs

  • D09 Carcinoma in situ of other and unspecified sites

  • D10 Benign neoplasm of mouth and pharynx

  • D11 Benign neoplasm of major salivary glands

  • D12 Benign neoplasm of colon, rectum, anus and anal canal

  • D13 Benign neoplasm of other and ill-defined parts of digestive system

  • D14 Benign neoplasm of middle ear and respiratory system

  • D15 Benign neoplasm of other and unspecified intrathoracic organs

  • D16 Benign neoplasm of bone and articular cartilage

  • D17 Benign lipomatous neoplasm

  • D18 Hemangioma and lymphangioma, any site

  • D19 Benign neoplasm of mesothelial tissue

  • D20 Benign neoplasm of soft tissue of retroperitoneum and peritoneum

  • D21 Other benign neoplasms of connective and other soft tissue

  • D22 Melanocytic nevi

  • D23 Other benign neoplasms of skin

  • D24 Benign neoplasm of breast

  • D25 Leiomyoma of uterus

  • D26 Other benign neoplasms of uterus

  • D27 Benign neoplasm of ovary

  • D28 Benign neoplasm of other and unspecified female genital organs

  • D29 Benign neoplasm of male genital organs

  • D30 Benign neoplasm of urinary organs

  • D31 Benign neoplasm of eye and adnexa

  • D32 Benign neoplasm of meninges

  • D33 Benign neoplasm of brain and other parts of central nervous system

  • D34 Benign neoplasm of thyroid gland

  • D35 Benign neoplasm of other and unspecified endocrine glands

  • D36 Benign neoplasm of other and unspecified sites

Categories D37-D44, and D48 classify by site neoplasms of uncertain behavior, i.e., histologic confirmation whether the neoplasm is malignant or benign cannot be made.

Excludes1

  • neoplasms of unspecified behavior (D49.-)
  • D37 Neoplasm of uncertain behavior of oral cavity and digestive organs

  • D38 Neoplasm of uncertain behavior of middle ear and respiratory and intrathoracic organs

  • D39 Neoplasm of uncertain behavior of female genital organs

  • D40 Neoplasm of uncertain behavior of male genital organs

  • D41 Neoplasm of uncertain behavior of urinary organs

  • D42 Neoplasm of uncertain behavior of meninges

  • D43 Neoplasm of uncertain behavior of brain and central nervous system

  • D44 Neoplasm of uncertain behavior of endocrine glands

  • D45 Polycythemia vera

  • D46 Myelodysplastic syndromes

  • D47 Other neoplasms of uncertain behavior of lymphoid, hematopoietic and related tissue

  • D48 Neoplasm of uncertain behavior of other and unspecified sites

  • D3A Benign neuroendocrine tumors

  • D49 Neoplasms of unspecified behavior

    Note: Category D49 classifies by site neoplasms of unspecified morphology and behavior. The term 'mass', unless otherwise stated, is not to be regarded as a neoplastic growth.