ICD-10-CM — Chapter 3

Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

Tabular List

Find your ICD-10-CM code by first selecting the most applicable chapter

Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism


  • autoimmune disease (systemic) NOS (M35.9)
  • certain conditions originating in the perinatal period (P00-P96)
  • complications of pregnancy, childbirth and the puerperium (O00-O9A)
  • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
  • endocrine, nutritional and metabolic diseases (E00-E88)
  • human immunodeficiency virus [HIV] disease (B20)
  • injury, poisoning and certain other consequences of external causes (S00-T88)
  • neoplasms (C00-D49)
  • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
Expand All Chapter #3 contains the following ICD-10-CM sections:
  • D50 Iron deficiency anemia

  • D51 Vitamin B12 deficiency anemia

  • D52 Folate deficiency anemia

  • D53 Other nutritional anemias

  • D55 Anemia due to enzyme disorders

  • D56 Thalassemia

  • D57 Sickle-cell disorders

  • D58 Other hereditary hemolytic anemias

  • D59 Acquired hemolytic anemia

  • D60 Acquired pure red cell aplasia [erythroblastopenia]

  • D61 Other aplastic anemias and other bone marrow failure syndromes

  • D62 Acute posthemorrhagic anemia

  • D63 Anemia in chronic diseases classified elsewhere

  • D64 Other anemias

  • D65 Disseminated intravascular coagulation [defibrination syndrome]

    Inclusion term(s):

    • Afibrinogenemia, acquired
    • Consumption coagulopathy
    • COVID-19 associated diffuse or disseminated intravascular coagulopathy
    • Diffuse or disseminated intravascular coagulation [DIC]
    • Fibrinolytic hemorrhage, acquired
    • Fibrinolytic purpura
    • Purpura fulminans
  • D66 Hereditary factor VIII deficiency

    Inclusion term(s):

    • Classical hemophilia
    • Deficiency factor VIII (with functional defect)
    • Hemophilia NOS
    • Hemophilia A
  • D67 Hereditary factor IX deficiency

    Inclusion term(s):

    • Christmas disease
    • Factor IX deficiency (with functional defect)
    • Hemophilia B
    • Plasma thromboplastin component [PTC] deficiency
  • D68 Other coagulation defects

  • D69 Purpura and other hemorrhagic conditions

  • D70 Neutropenia

  • D71 Functional disorders of polymorphonuclear neutrophils

    Inclusion term(s):

    • Cell membrane receptor complex [CR3] defect
    • Chronic (childhood) granulomatous disease
    • Congenital dysphagocytosis
    • Progressive septic granulomatosis
  • D72 Other disorders of white blood cells

  • D73 Diseases of spleen

  • D74 Methemoglobinemia

  • D75 Other and unspecified diseases of blood and blood-forming organs

  • D76 Other specified diseases with participation of lymphoreticular and reticulohistiocytic tissue

  • D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere

  • D78 Intraoperative and postprocedural complications of the spleen


  • defects in the complement system
  • immunodeficiency disorders, except human immunodeficiency virus [HIV] disease
  • sarcoidosis


  • autoimmune disease (systemic) NOS (M35.9)
  • functional disorders of polymorphonuclear neutrophils (D71)
  • human immunodeficiency virus [HIV] disease (B20)
  • D80 Immunodeficiency with predominantly antibody defects

  • D81 Combined immunodeficiencies

  • D82 Immunodeficiency associated with other major defects

  • D83 Common variable immunodeficiency

  • D84 Other immunodeficiencies

  • D86 Sarcoidosis

  • D89 Other disorders involving the immune mechanism, not elsewhere classified